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  Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences

Pallares, L. F., Turner, L. M., & Tautz, D. (2016). Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences. Development Genes and Evolution, 226(3), 173-186. doi:10.1007/s00427-016-0550-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B9DF-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B9E0-D
Genre: Journal Article

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 Creators:
Pallares, Luisa F.1, Author              
Turner, Leslie M.1, Author              
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Complex traits; Geometric morphometrics; Mandible shape; Quantitative genetics; Skull shape
 Abstract: Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.

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Language(s): eng - English
 Dates: 2016-02-142016-05-092016-05-232016-06
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1007/s00427-016-0550-7
BibTex Citekey: Pallares2016
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Title: Development Genes and Evolution
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: - Volume / Issue: 226 (3) Sequence Number: - Start / End Page: 173 - 186 Identifier: ISSN: 0949-944X
CoNE: /journals/resource/954926988121