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  Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

Gupta, Y., Möller, S., Witte, M., Belheouane, M., Sezin, T., Hirose, M., et al. (2016). Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease. BMC Genomics, 17(1), 1-14. doi:10.1186/s12864-016-2455-2.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-84B0-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-84B1-9
Genre: Journal Article

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 Creators:
Gupta, Yask, Author
Möller, Steffen, Author
Witte, Mareike, Author
Belheouane, Meriem1, Author              
Sezin, Tanya, Author
Hirose, Misa, Author
Vorobyev, Artem, Author
Niesar, Felix, Author
Bischof, Julia, Author
Ludwig, Ralf J, Author
Zillikens, Detlef, Author
Sadik, Christian D, Author
Restle, Tobias, Author
Häsler, Robert, Author
Baines, John F.1, Author              
Ibrahim, Saleh M, Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: MicroRNA; Expression; QTL Epistasis; Autoimmune skin blistering disease; Co-expression analysis
 Abstract: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that control genes at post-transcriptional level. They are essential for development and tissue differentiation, and such altered miRNA expression patterns are linked to the pathogenesis of inflammation and cancer. There is evidence that miRNA expression is genetically controlled similar to the transcription of protein-coding genes and previous studies identified quantitative trait loci (QTL) for miRNA expression in the liver. So far, little attention has been paid to miRNA expression in the skin. Moreover, epistatic control of miRNA expression remains unknown. In this study, we characterize genetic regulation of cutaneous miRNA and their correlation with skin inflammation using a previously established murine autoimmune-prone advanced intercross line.

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Language(s): eng - English
 Dates: 2016-04-182016-02-092016-02-162016
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/s12864-016-2455-2
BibTex Citekey: Gupta2016
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Title: BMC Genomics
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 17 (1) Sequence Number: - Start / End Page: 1 - 14 Identifier: ISSN: 1471-2164
CoNE: /journals/resource/111000136905010