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  The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity

Hanschen, E. R., Marriage, T. N., Ferris, P. J., Hamaji, T., Toyoda, A., Fujiyama, A., et al. (2016). The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nature Communications, 7: 11370. doi:10.1038/ncomms11370.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E5F9-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1508-2
Genre: Journal Article

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 Creators:
Hanschen, Erik R., Author
Marriage, Tara N., Author
Ferris, Patrick J., Author
Hamaji, Takashi, Author
Toyoda, Atsushi, Author
Fujiyama, Asao, Author
Neme, Rafik1, Author              
Noguchi, Hideki, Author
Minakuchi, Yohei, Author
Suzuki, Masahiro, Author
Kawai-Toyooka, Hiroko, Author
Smith, David R., Author
Sparks, Halle, Author
Anderson, Jaden, Author
Bakaric, Robert, Author
Luria, Victor, Author
Karger, Amir, Author
Kirschner, Marc W., Author
Durand, Pierre M., Author
Michod, Richard E., Author
Nozaki, Hisayoshi, AuthorOlson, Bradley J. S. C., Author more..
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Biological sciences; Evolution; Genetics
 Abstract: The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes it to become colonial. The presence of these changes in undifferentiated Gonium indicates extensive group-level adaptation during the initial step in the evolution of multicellularity. These results emphasize an early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation, one that may shed light on the evolutionary history of other multicellular innovations and evolutionary transitions.

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Language(s): eng - English
 Dates: 2016-01-262016-03-182016-04-222016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ncomms11370
BibTex Citekey: Hanschen2016
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 10 Seiten Volume / Issue: 7 Sequence Number: 11370 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723