English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Zbtb20 modulates the sequential generation of neuronal layers in developing cortex.

Tonchev, A. B., Tuoc, T. C., Rosenthal, E. H., Studer, M., & Stoykova, A. (2016). Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Molecular Brain, 9: 65. doi:10.1186/s13041-016-0242-2.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E7AD-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2649-6
Genre: Journal Article

Files

show Files
hide Files
:
2306184.pdf (Publisher version), 4MB
Name:
2306184.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Tonchev, A. B.1, Author              
Tuoc, T. C.1, Author              
Rosenthal, E. H., Author
Studer, M., Author
Stoykova, A.1, Author              
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

Content

show
hide
Free keywords: Zbtb20; Development; Neocortex; Temporal identity; Transcription factor
 Abstract: BACKGROUND: During corticogenesis, genetic programs encoded in progenitor cells at different developmental stages and inherited in postmitotic neurons specify distinct layer and area identities. Transcription factor Zbtb20 has been shown to play a role for hippocampal development but whether it is implicated in mammalian neocortical morphogenesis remains unknown. RESULTS: Here, we report that during embyogenesis transcription factor Zbtb20 has a dynamic spatio-temporal expression pattern in mitotic cortical progenitors through which it modulates the sequential generation of cortical neuronal layer identities. Zbtb20 knock out mice exhibited enhanced populations of early born L6-L4 neuronal subtypes and a dramatic reduction of the late born L3/L2 neurons. This defect was due to a temporal misbalance in the production of earlier versus later born neurons, leading to a progressive diminishing of the progenitor pool for the generation of L3-L2 neurons. Zbtb20 implements these temporal effects in part by binding to promoter of the orphan nuclear receptor CoupTF1/Nr2f1. In addition to its effects exerted in cortical progenitors, the postmitotic expression of Zbtb20 in L3/L2 neurons starting at birth may contribute to their proper differentiation and migration. CONCLUSIONS: Our findings reveal Zbtb20 as a novel temporal regulator for the generation of layer-specific neuronal identities.

Details

show
hide
Language(s): eng - English
 Dates: 2016-06-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s13041-016-0242-2
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Brain
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 15 Volume / Issue: 9 Sequence Number: 65 Start / End Page: - Identifier: -