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  Ionotropic chemosensory receptors mediate the taste and smell of polyamines

Hussain, A., Zhang, M., Ucpunar, H., Svensson, T., Quillery, E., Gompel, N., et al. (2016). Ionotropic chemosensory receptors mediate the taste and smell of polyamines. PLoS Biology, 14(5): e1002454. doi:10.1371/journal.pbio.1002454.

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© 2016 Hussain et al. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Hussain, Ashiq1, Author           
Zhang, Mo1, Author           
Ucpunar, Habibe1, Author           
Svensson, Thomas, Author
Quillery, Elsa, Author
Gompel, Nicolas, Author
Ignell, Rickard, Author
Grunwald Kadow, Ilona C.1, Author           
Affiliations:
1Max Planck Research Group: Chemosensory coding / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: MALE COURTSHIP BEHAVIOR; D-ASPARTATE RECEPTOR; GLUTAMATE RECEPTORS; AEDES-AEGYPTI; MOLECULAR-BASIS; SENSE-ORGANS; BITTER TASTE; OLFACTORY RECEPTOR; DROSOPHILA-ANTENNA; DIPTERA-CULICIDAEBiochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics;
 Abstract: The ability to find and consume nutrient-rich diets for successful reproduction and survival is fundamental to animal life. Among the nutrients important for all animals are polyamines, a class of pungent smelling compounds required in numerous cellular and organismic processes. Polyamine deficiency or excess has detrimental effects on health, cognitive function, reproduction, and lifespan. Here, we show that a diet high in polyamine is beneficial and increases reproductive success of flies, and we unravel the sensory mechanisms that attract Drosophila to polyamine-rich food and egg-laying substrates. Using a combination of behavioral genetics and in vivo calcium imaging, we demonstrate that Drosophila uses multisensory detection to find and evaluate polyamines present in overripe and fermenting fruit, their favored feeding and egg-laying substrate. In the olfactory system, two coexpressed ionotropic receptors (IRs), IR76b and IR41a, mediate the long-range attraction to the odor. In the gustatory system, multimodal taste sensation by IR76b receptor and GR66a bitter receptor neurons is used to evaluate quality and valence of the polyamine providing a mechanism for the fly's high attraction to polyamine-rich and sweet decaying fruit. Given their universal and highly conserved biological roles, we propose that the ability to evaluate food for polyamine content may impact health and reproductive success also of other animals including humans.

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Language(s): eng - English
 Dates: 2016-05-04
 Publication Status: Published in print
 Pages: 30
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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: Public Library of Science
Pages: - Volume / Issue: 14 (5) Sequence Number: e1002454 Start / End Page: - Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170