English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The actin-binding cleft: functional characterisation of myosin II with a strut mutation

Fujita-Becker, S., Reubold, T., & Holmes, K. C. (2006). The actin-binding cleft: functional characterisation of myosin II with a strut mutation. Journal of Muscle Research and Cell Motility, 27(2), 115-123. doi:10.1007/s10974-005-9047-0.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E89B-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E89C-3
Genre: Journal Article
Alternative Title : The actin-binding cleft: functional characterisation of myosin II with a strut mutation

Files

show Files
hide Files
:
JMuscleResCellMotil_27_2006_115.pdf (Any fulltext), 459KB
 
File Permalink:
-
Name:
JMuscleResCellMotil_27_2006_115.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, Heidelberg; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Fujita-Becker, Setsuko1, Author              
Reubold, Thomas1, Author              
Holmes, Kenneth C.1, Author              
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

Content

show
hide
Free keywords: -
 Abstract: The myosin cross-bridge has two essential properties: to undergo the "power stroke" and to bind and release from actin - both under control of ATP binding and hydrolysis. In the absence of ATP the cross-bridge binds to actin with high affinity: the binding of ATP causes rapid release of the cross-bridge from actin. The actin binding-site is split by a deep cleft that closes on strong binding to actin. The cleft is straddled by a short polypeptide known as the "strut". In the following we summarise the structural basis of the power stroke and the control of actin affinity and then present data on the effects on actin affinity of replacing the strut by a flexible linker.

Details

show
hide
Language(s): eng - English
 Dates: 2005-08-032005-11-032006-02-012006-02-01
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Muscle Research and Cell Motility
  Other : J. Muscle Res. Cell Motil.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Chapman and Hall
Pages: - Volume / Issue: 27 (2) Sequence Number: - Start / End Page: 115 - 123 Identifier: ISSN: 0142-4319
CoNE: /journals/resource/954925472360