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  The actin-binding cleft: functional characterisation of myosin II with a strut mutation

Fujita-Becker, S., Reubold, T., & Holmes, K. C. (2006). The actin-binding cleft: functional characterisation of myosin II with a strut mutation. Journal of Muscle Research and Cell Motility, 27(2), 115-123. doi:10.1007/s10974-005-9047-0.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-E89B-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-E89C-3
Genre: Journal Article
Alternative Title : The actin-binding cleft: functional characterisation of myosin II with a strut mutation

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JMuscleResCellMotil_27_2006_115.pdf (Any fulltext), 459KB
 
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https://dx.doi.org/10.1007/s10974-005-9047-0 (Any fulltext)
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 Creators:
Fujita-Becker, Setsuko1, Author           
Reubold, Thomas1, Author           
Holmes, Kenneth C.1, Author           
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1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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 Abstract: The myosin cross-bridge has two essential properties: to undergo the "power stroke" and to bind and release from actin - both under control of ATP binding and hydrolysis. In the absence of ATP the cross-bridge binds to actin with high affinity: the binding of ATP causes rapid release of the cross-bridge from actin. The actin binding-site is split by a deep cleft that closes on strong binding to actin. The cleft is straddled by a short polypeptide known as the "strut". In the following we summarise the structural basis of the power stroke and the control of actin affinity and then present data on the effects on actin affinity of replacing the strut by a flexible linker.

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Language(s): eng - English
 Dates: 2005-08-032005-11-032006-02-012006-02-01
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665391
DOI: 10.1007/s10974-005-9047-0
URI: http://www.ncbi.nlm.nih.gov/pubmed/16450056
URI: http://www.springerlink.com/content/h356236uh4085466/
URI: http://link.springer.com/article/10.1007%2Fs10974-005-9047-0
Other: 6649
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Title: Journal of Muscle Research and Cell Motility
  Other : J. Muscle Res. Cell Motil.
Source Genre: Journal
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Publ. Info: London : Chapman and Hall
Pages: - Volume / Issue: 27 (2) Sequence Number: - Start / End Page: 115 - 123 Identifier: ISSN: 0142-4319
CoNE: https://pure.mpg.de/cone/journals/resource/954925472360