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  Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy

Lu, A. H., Zhang, X.-Q., Sun, Q., Zhang, Y., Song, Q., Schüth, F., et al. (2016). Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy. Nano Research, 9(5), 1460-1469. doi:10.1007/s12274-016-1042-9.

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 Creators:
Lu, A. H.1, 2, Author              
Zhang, Xiang-Qian1, Author
Sun, Qiang1, Author              
Zhang, Yan3, Author              
Song, Qingwei3, Author
Schüth, Ferdi2, Author              
Chen, Chunying4, 5, Author
Cheng, Fang6, Author
Affiliations:
1Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, Fac Chem Environm & Biol Sci, Dalian 116024, Peoples R China, ou_persistent22              
2Research Department Schüth, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445589              
3Dalian Med Univ, Hosp 1, Dalian 116021, Peoples R China, ou_persistent22              
4Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China, ou_persistent22              
5Chinese Acad Sci, Inst High Energy Phys, Beijing 100190, Peoples R China, ou_persistent22              
6Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China, ou_persistent22              

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Free keywords: magnetic nanoparticles carbon Fe3O4 magnetic resonance imaging (MRI) colloidal suspensions photothermal therapy
 Abstract: Carbon-protected magnetic nanoparticles exhibit long-term stability in acid or alkaline medium, good biocompatibility, and high saturation magnetization. As a result, they hold great promise for magnetic resonance imaging, photothermal therapy, etc. However, since pyrolysis, which is often required to convert the carbon precursors to carbon, typically leads to coalescence of the nanoparticles, the obtained carbon-protected magnetic nanoparticles are usually sintered as a non-dispersible aggregation. We have successfully synthesized discrete, dispersible, and uniform carbon-protected magnetic nanoparticles via a precise surface/interface nano-engineering approach. Remarkably, the nanoparticles possess excellent water-dispersibility, biocompatibility, a high T (2) relaxivity coefficient (384 mM(-1)center dot s(-1)), and a high photothermal heating effect. Furthermore, they can be used as multifunctional core components suited for future extended investigation in early diagnosis, detection and therapy, catalysis, separation, and magnetism.

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Language(s): eng - English
 Dates: 2016-03-292016-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s12274-016-1042-9
 Degree: -

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Title: Nano Research
Source Genre: Journal
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Publ. Info: Tsinghua University Press
Pages: - Volume / Issue: 9 (5) Sequence Number: - Start / End Page: 1460 - 1469 Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/1000000000224290
ISSN: 1998-0124