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  Longitudinal changes in resting-state fMRI from age 5 to age 6 years covary with language development

Xiao, Y., Friederici, A. D., Margulies, D. S., & Brauer, J. (2016). Longitudinal changes in resting-state fMRI from age 5 to age 6 years covary with language development. NeuroImage, 128, 116-124. doi:10.1016/j.neuroimage.2015.12.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EAD1-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1DE9-7
Genre: Journal Article

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 Creators:
Xiao, Yaqiong1, Author              
Friederici, Angela D.1, Author              
Margulies, Daniel S.2, Author              
Brauer, Jens1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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Free keywords: Preschool children; Language development; Resting-state fMRI; Intrinsic connectivity; Frontal-to-temporal connection
 Abstract: Resting-state functional magnetic resonance imaging is a powerful technique to study the whole-brain neural connectivity that underlies cognitive systems. The present study aimed to define the changes in neural connectivity in their relation to language development. Longitudinal resting-state functional data were acquired from a cohort of preschool children at age 5 and one year later, and changes in functional connectivity were correlated with language performance in sentence comprehension. For this, degree centrality, a voxel-based network measure, was used to assess age-related differences in connectivity at the whole-brain level. Increases in connectivity with age were found selectively in a cluster within the left posterior superior temporal gyrus and sulcus (STG/STS). In order to further specify the connection changes, a secondary seed-based functional connectivity analysis on this very cluster was performed. The correlations between resting-state functional connectivity (RSFC) and language performance revealed developmental effects with age and, importantly, also dependent on the advancement in sentence comprehension ability over time. In children with greater advancement in language abilities, the behavioral improvement was positively correlated with RSFC increase between left posterior STG/STS and other regions of the language network, i.e., left and right inferior frontal cortex. The age-related changes observed in this study provide evidence for alterations in the language network as language develops and demonstrates the viability of this approach for the investigation of normal and aberrant language development.

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Language(s): eng - English
 Dates: 2015-08-132015-12-062015-12-122016-03-01
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.12.008
PMID: 26690809
PMC: PMC4767215
Other: Epub 2015
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 128 Sequence Number: - Start / End Page: 116 - 124 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166