English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Learning from stargazin: the mouse, the phenotype and the unexpected

Osten, P., & Stern-Bach, Y. (2006). Learning from stargazin: the mouse, the phenotype and the unexpected. Current Opinion in Neurobiology, 16(3), 275-280. doi:10.1016/j.conb.2006.04.002.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EBD7-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EBD8-1
Genre: Journal Article

Files

show Files
hide Files
:
CurrOpinNeurobiol_16_2006_275.pdf (Any fulltext), 181KB
 
File Permalink:
-
Name:
CurrOpinNeurobiol_16_2006_275.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Osten, Pavel1, Author              
Stern-Bach, Yael, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC), and a deficit in its role as auxiliary VDCC subunit was proposed to underlie the epileptic phenotype of the mouse; yet, a conclusive demonstration of stargazin function in VDCC regulation is still lacking. In contrast, stargazin and its three closely related isoforms gamma-3, gamma-4 and gamma-8 were shown to function as auxiliary subunits for a very different ion channel - the AMPA-type glutamate receptor - prominently regulating early intracellular transport, synaptic targeting and anchoring, and ion channel functions of this major excitatory receptor in the brain.

Details

show
hide
Language(s):
 Dates: 2006-05-052006-06-01
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Current Opinion in Neurobiology
  Other : Curr. Opin.Neurobiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Elsevier Current Trends
Pages: - Volume / Issue: 16 (3) Sequence Number: - Start / End Page: 275 - 280 Identifier: ISSN: 0959-4388
CoNE: https://pure.mpg.de/cone/journals/resource/954925578066