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  Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse

Sanchis-Segura, C., Borchardt, T., Vengeliene, V., Zghoul, T., Bachteler, D., Gass, P., et al. (2006). Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 26(4), 1231-1238. doi:10.1523/JNEUROSCI.4237-05.2006.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-ED31-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-ED32-5
Genre: Journal Article
Alternative Title : Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse

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 Creators:
Sanchis-Segura, Carles, Author
Borchardt, Thilo1, Author           
Vengeliene, Valentina, Author
Zghoul, Tarek, Author
Bachteler, Daniel, Author
Gass, Peter, Author
Sprengel, Rolf1, Author           
Spanagel, Rainer, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AMPA; ethanol relapse; alcohol deprivation effect (ADE); reinstatement; GluR-C; addiction
 Abstract: Craving and relapse are core symptoms of drug addiction and alcoholism. It is suggested that, after chronic drug consumption, long-lasting neuroplastic changes within the glutamatergic system are important determinants of addictive behavior. Here, we show that the AMPA type glutamate receptor plays a crucial role in alcohol craving and relapse. We observed, in two animal models of alcohol craving and relapse, that the AMPA antagonist GYKI 52466 [1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2, 3-benzodiazepine] dose-dependently reduced cue-induced reinstatement of alcohol-seeking behavior and the alcohol deprivation effect. The involvement of the AMPA receptor in these phenomena was further studied using mice deficient for the GluR-C AMPA subunit [GluR-C knock-out (KO)]. GluR-C KOs displayed a blunted, cue-induced reinstatement response and alcohol deprivation effect, when compared with wild-type controls; however, no differences between genotypes could be observed regarding ethanol self-administration under operant or home cage drinking conditions. These results imply a role for GluR-C in alcohol relapse, although this phenotype could also be attributable to a reduction in the total number of AMPA receptors in specific brain areas. In conclusion, AMPA receptors seem to be involved in the neuroplastic changes underlying alcohol seeking behavior and relapse. Thus, AMPA receptors represent a novel therapeutic target in preventing relapse.

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Language(s): eng - English
 Dates: 2005-11-222005-07-042005-11-222006-01-25
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665479
DOI: 10.1523/JNEUROSCI.4237-05.2006
URI: http://www.ncbi.nlm.nih.gov/pubmed/16436610
URI: http://www.jneurosci.org/content/26/4/1231.abstract
URI: http://www.jneurosci.org/content/26/4/1231.full
Other: 6527
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 26 (4) Sequence Number: - Start / End Page: 1231 - 1238 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1