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  Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision

Schaefer, A. T., Angelo, K., Spors, H., & Margrie, T. W. (2006). Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision. PLoS Biology, 4(6): e163, pp. 1010-1024. doi:10.1371/journal.pbio.0040163.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-ED8D-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-ED8E-A
Genre: Journal Article
Alternative Title : Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision

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PLoSBiol_4_2006_163e.pdf (Any fulltext), 792KB
 
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 Creators:
Schaefer, Andreas T.1, Author              
Angelo, Kamilla, Author
Spors, Hartwig1, 2, Author              
Margrie, Troy W.1, 3, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
3Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically generated membrane potential oscillations dramatically improve action potential (AP) precision by removing the membrane potential variance associated with jitter-accumulating trains of APs. This increased AP precision occurred irrespective of cell type and--at oscillation frequencies ranging from 3 to 65 Hz--permitted accurate discernment of up to 1,000 different stimuli. At low oscillation frequencies, stimulus discrimination showed a clear phase dependence whereby inputs arriving during the trough and the early rising phase of an oscillation cycle were most robustly discriminated. Thus, by ensuring AP precision, membrane potential oscillations dramatically enhance the discriminatory capabilities of individual neurons and networks of cells and provide one attractive explanation for their abundance in neurophysiological systems.

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Language(s): eng - English
 Dates: 2005-09-222006-03-172006-05-162006-06-01
 Publication Status: Published in print
 Pages: 15
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 Table of Contents: -
 Rev. Method: Peer
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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: Public Library of Science
Pages: - Volume / Issue: 4 (6) Sequence Number: e163 Start / End Page: 1010 - 1024 Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170