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  Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons

Shimshek, D. R., Bus, T., Grinevich, V., Single, F. N., Mack, V., Sprengel, R., et al. (2006). Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Molecular Endocrinology, 20(1), 219-231. doi:10.1210/me.2005-0262.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EDAD-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EDB0-B
Genre: Journal Article
Alternative Title : Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons

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 Creators:
Shimshek, Derya R.1, Author              
Bus, Thorsten2, Author              
Grinevich, Valery1, Author              
Single, Frank Nicolai1, Author              
Mack, Volker1, Author              
Sprengel, Rolf1, Author              
Spergel, Daniel J.1, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              

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 Abstract: The roles of ionotropic glutamate receptors in mammalian reproduction are unknown. We therefore generated mice lacking a major subtype of (S)-alpha-amino-3-hydroxy-5-methyl-isoxazolepropionic acid (AMPA) receptors or all N-methyl-d-aspartate (NMDA) receptors in GnRH neurons and other mainly limbic system neurons, primarily in hypothalamic and septal areas. Male mice without NMDA receptors in these neurons were not impaired in breeding and exhibited similar GnRH secretion as control littermates. However, male mice lacking GluR-B containing AMPA receptors in these neurons were poor breeders and severely impaired in reproductive behaviors such as aggression and mounting. Testis and sperm morphology, testis weight, and serum testosterone levels, as well as GnRH secretion, were unchanged. Contact with female cage bedding failed to elicit male sexual behavior in these mice, unlike in control male littermates. Their female counterparts had unchanged ovarian morphology, had bred successfully, and had normal litter sizes but exhibited pronounced impairments in maternal behaviors such as pup retrieval and maternal aggression. Our results suggest that NMDA receptors and GluR-B containing AMPA receptors are not essential for fertility, but that GluR-B containing AMPA receptors are essential for male and female reproduction-related behaviors, perhaps by mediating responses to pheromones or odorants.

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Language(s): eng - English
 Dates: 2005-07-012005-08-042005-08-112006-01-01
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 665417
DOI: 10.1210/me.2005-0262
URI: http://www.ncbi.nlm.nih.gov/pubmed/16099814
URI: hhttp://press.endocrine.org/doi/abs/10.1210/me.2005-0262
URI: http://press.endocrine.org/doi/full/10.1210/me.2005-0262
Other: 6647
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Title: Molecular Endocrinology
Source Genre: Journal
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Publ. Info: Baltimore, MD : Endocrine Society
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 219 - 231 Identifier: ISSN: 0888-8809
CoNE: /journals/resource/954925555416