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  Tetracycline-controlled genetic switches

Sprengel, R., & Hasan, M. T. (2007). Tetracycline-controlled genetic switches. In D. M. Robert Feil (Ed.), Conditional Mutagenesis: an Approach to Disease Models (pp. 49-72). Berlin Heidelberg New York: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EE1E-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-EE1F-7
Genre: Book Chapter
Alternative Title : The tetracycline inducible system

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HdbkExperimentPharmacol_178_2007_49.pdf (Any fulltext), 450KB
 
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 Creators:
Sprengel, Rolf1, Author              
Hasan, Mazahir T.1, 2, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: Doxycycline − Luciferase − β−Galactosidase − GFP − Rosa26
 Abstract: Unlike recombinase-mediated gene manipulations, tetracycline (Tet)-controlled genetic switches permit reversible control of gene expression in the mouse. Trancriptional activation can be induced by activators termed tTA (Tet-Off) or rtTA (Tet-On) in the absence and presence of Tet, respectively. The Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both systems were optimized over the years and can now be used to develop mouse models.

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Language(s): eng - English
 Dates: 200620062007-02-01
 Publication Status: Published in print
 Pages: 24
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Source 1

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Title: Conditional Mutagenesis: an Approach to Disease Models
Source Genre: Book
 Creator(s):
Rolf Sprengel, Mazahir T. Hasan, Author
Robert Feil, Daniel Metzger, Editor
Affiliations:
-
Publ. Info: Berlin Heidelberg New York : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 49 - 72 Identifier: ISBN: 978-3-540-35108-5

Source 2

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Title: Handbook of Experimental Pharmacology
Source Genre: Series
 Creator(s):
Barrett, J.E, Editor
Flockerzi, V., Editor
Frohman, M.A., Editor
Geppetti, P., Editor
Hofmann, F.B., Editor
Michel, M.C., Editor
Page, C.P., Editor
Wang, K., Author
Affiliations:
-
Publ. Info: Berlin Heidelberg New York : Springer
Pages: - Volume / Issue: 178 Sequence Number: - Start / End Page: - Identifier: ISBN: 0171-2004