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  Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

Yang, W., Chendrimada, T. P., Wang, Q., Higuchi, M., Seeburg, P. H., Shiekhattar, R., et al. (2006). Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Structural and Molecular Biology, 13(1), 13-21. doi:10.1038/nsmb1041.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-EE6B-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-EE6C-A
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http://www.nature.com/nsmb/journal/v13/n1/pdf/nsmb1041.pdf (Any fulltext)
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 Creators:
Yang, Weidong, Author
Chendrimada, Thimmaiah P, Author
Wang, Qingde, Author
Higuchi, Miyoko1, Author           
Seeburg, Peter H.1, Author           
Shiekhattar, Ramin, Author
Nishikura, Kazuko, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Adenosine deaminases acting on RNA (ADARs) are involved in editing of adenosine residues to inosine in double-stranded RNA (dsRNA). Although this editing recodes and alters functions of several mammalian genes, its most common targets are noncoding repeat sequences, indicating the involvement of this editing system in currently unknown functions other than recoding of protein sequences. Here we show that specific adenosine residues of certain microRNA (miRNA) precursors are edited by ADAR1 and ADAR2. Editing of pri-miR-142, the precursor of miRNA-142, expressed in hematopoietic tissues, resulted in suppression of its processing by Drosha. The edited pri-miR-142 was degraded by Tudor-SN, a component of RISC and also a ribonuclease specific to inosine-containing dsRNAs. Consequently, mature miRNA-142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis.

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Language(s): eng - English
 Dates: 2005-12-202005-12-202006-01-13
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nsmb1041
URI: http://www.ncbi.nlm.nih.gov/pubmed/16369484
URI: http://www.nature.com/nsmb/journal/v13/n1/full/nsmb1041.html
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Title: Nature Structural and Molecular Biology
  Other : Nature Struct Biol
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 13 (1) Sequence Number: - Start / End Page: 13 - 21 Identifier: ISSN: 1545-9993
CoNE: https://pure.mpg.de/cone/journals/resource/954925603763