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  Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences

Poznik, G. D., Xue, Y., Mendez, F. L., Willems, T. F., Massaia, A., Wilson Sayres, M. A., et al. (2016). Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nature Genetics, 48(6), 593-599. doi:10.1038/ng.3559.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-F024-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-F025-A
Genre: Journal Article

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 Creators:
Poznik, G. D., Author
Xue, Y., Author
Mendez, F. L., Author
Willems, T. F., Author
Massaia, A., Author
Wilson Sayres, M. A., Author
The 1000 Genomes Projekt, Consortium, Author
Lehrach, H.1, Author              
Sudbrak, R., Author
Albrecht, M. W., Author
Amstislavskiy, V.2, Author              
Borodina, T. A., Author
Lienhard, M.3, Author              
Mertes, F.1, Author              
Sultan, M., Author
Timmermann, B.4, Author              
Yaspo, M.-L.2, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117287              
3Bioinformatics (Ralf Herwig), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              
4Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a calibrated phylogenetic tree on the basis of binary single-nucleotide variants and projected the more complex variants onto it, estimating the number of mutations for each class. Our phylogeny shows bursts of extreme expansion in male numbers that have occurred independently among each of the five continental superpopulations examined, at times of known migrations and technological innovations.

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Language(s): eng - English
 Dates: 2016-04-252016-06
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ng.3559
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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 48 (6) Sequence Number: - Start / End Page: 593 - 599 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609