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  A sustainable, semi-continuous flow synthesis of hydantoins

Vukelić, S., Koksch, B., Seeberger, P. H., Seeberger, P. H., & Gilmore, K. (2016). A sustainable, semi-continuous flow synthesis of hydantoins. Chemistry – A European Journal, 22(38), 13451-13454. doi:10.1002/chem.201602609.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-F4ED-E Version Permalink: http://hdl.handle.net/21.11116/0000-0006-598D-8
Genre: Journal Article

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2307729.pdf (Publisher version), 464KB
 
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 Creators:
Vukelić, Stella1, Author              
Koksch, Beate, Author
Seeberger, Peter H., Author              
Seeberger, Peter H.2, Author              
Gilmore, Kerry1, Author              
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: Hydandoins, flow chemistry, multiphase chemistry, carbon dioxide
 Abstract: Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps, often use reagents that are not commercially available, and are not sustainable. Herein, an efficient process is described accessing hydantoins starting from commercially available amines using consecutive gas/liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52-84%).

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 Dates: 2016-06-242016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/chem.201602609
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Title: Chemistry – A European Journal
  Other : Chem. – Eur. J.
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim : VCH
Pages: - Volume / Issue: 22 (38) Sequence Number: - Start / End Page: 13451 - 13454 Identifier: ISSN: 0947-6539