ausblenden:
Schlagwörter:
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Zusammenfassung:
Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1
(NMDAR1) are highly seroprevalent in health and disease. Symptomatic
relevance may arise upon compromised blood-brain barrier (BBB). However,
it remained unknown whether circulating NMDAR1 AB appear in the
cerebrospinal fluid (CSF). Of n5271 subjects with CSF-serum pairs, 26
were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise,
tetanus AB (non-brain-binding) were present in serum and CSF of all
subjects, with CSF levels higher upon BBB dysfunction. Translational
mouse experiments proved the hypothesis that the brain acts as an
'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the
non-brain-binding green fluorescent protein AB resulted in high
detectability of the former in brain and the latter in CSF.
