ausblenden:
Schlagwörter:
Transdiagnostic analysis, resting state functional connectivity, fMRI, default mode network, schizophrenia, major depression
Zusammenfassung:
Schizophrenia and depression are prevalent psychiatric disorders, but
their underlying neural bases remains poorly understood. Neuroimaging
evidence has pointed towards the relevance of functional connectivity
aberrations in defaultmode network (DMN) hubs, dorso-medial prefrontal
cortex and precuneus, in both disorders, but commonalities and
differences in resting state functional connectivity of those two
regions across disorders has not been formally assessed. Here, we took a
transdiagnostic approach to investigate resting state functional
connectivity of those two regions in 75 patients with schizophrenia and
82 controls from 4 scanning sites and 102 patients with depression and
106 controls from 3 sites. Our results demonstrate common
dysconnectivity patterns as indexed by a significant reduction of
functional connectivity between precuneus and bilateral superior
parietal lobe in schizophrenia and depression. Furthermore, our findings
highlight diagnosis-specific connectivity reductions of the parietal
operculum in schizophrenia relative to depression. In light of evidence
that points towards the importance of the DMN for social cognitive
abilities and well documented impairments of social interaction in both
patient groups, it is conceivable that the observed transdiagnostic
connectivity alterations may contribute to interpersonal difficulties,
but this could not be assessed directly in our study as measures of
social behavior were not available. Given the operculum's role in
somatosensory integration, diagnosis-specific connectivity reductions
may indicate a pathophysiological mechanism for basic self-disturbances
that is characteristic of schizophrenia, but not depression. (C) 2015
The Authors. Published by Elsevier Inc.
