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  Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen

Auer, M. K., Hellweg, R., Briken, P., Stalla, G. K., T'Sjoen, G., & Fuss, J. (2016). Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen. BIOLOGY OF SEX DIFFERENCES, 7: 1. doi:10.1186/s13293-015-0055-5.

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 Urheber:
Auer, Matthias K.1, Autor           
Hellweg, Rainer2, Autor
Briken, Peer2, Autor
Stalla, Günter K.1, Autor           
T'Sjoen, Guy2, Autor
Fuss, Johannes2, Autor
Affiliations:
1Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035296              
2external, ou_persistent22              

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Schlagwörter: Transsexualism, Estradiiol, Sex Steroids, Testosterone, Brain-derived neurotropic factor, BDNF, Gender dysphoria, Brain morphology, Platelets
 Zusammenfassung: Brain morphology significantly differs between the sexes. It has been shown before that some of these differences are attributable to the sex-specific hormonal milieu. Brain-derived neurotrophic factor (BDNF) is involved in myriads of neuroplastic processes and shows a sexual dimorphism. Transsexual persons may serve as a model to study sex steroid-mediated effects on brain plasticity. We have recently demonstrated that serum levels of BDNF are reduced in transwomen following 12 months of cross-sex hormone treatment. We now wanted to look at the effects of testosterone treatment on BDNF in transmen. In contrast to our initial hypothesis, BDNF levels did not significantly change, despite dramatic changes in the sex-hormonal milieu. Our data indicate that testosterone does not seem to play a major role in the regulation of BDNF in females.

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Sprache(n): eng - English
 Datum: 2016-01-08
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000367707400001
DOI: 10.1186/s13293-015-0055-5
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Titel: BIOLOGY OF SEX DIFFERENCES
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: BioMed Central
Seiten: - Band / Heft: 7 Artikelnummer: 1 Start- / Endseite: - Identifikator: ISSN: 2042-6410