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  Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Schwantes-An, T.-H., Zhang, J., Chen, L.-S., Hartz, S. M., Culverhouse, R. C., Chen, X., Coon, H., Frank, J., Kamens, H. M., Konte, B., Kovanen, L., Latvala, A., Legrand, L. N., Maher, B. S., Melroy, W. E., Nelson, E. C., Reid, M. W., Robinson, J. D., Shen, P.-H., Yang, B.-Z., Andrews, J. A., Aveyard, P., Beltcheva, O., Brown, S. A., Cannon, D. S., Cichon, S., Corley, R. P., Dahmen, N., Degenhardt, L., Foroud, T., Gaebel, W., Giegling, I., Glatt, S. J., Grucza, R. A., Hardin, J., Hartmann, A. M., Heath, A. C., Herms, S., Hodgkinson, C. A., Hoffmann, P., Hops, H., Huizinga, D., Ising, M., Johnson, E. O., Johnstone, E., Kaneva, R. P., Kendler, K. S., Kiefer, F., Kranzler, H. R., Krauter, K. S., Levran, O., Lucae, S., Lynskey, M. T., Maier, W., Mann, K., Martin, N. G., Mattheisen, M., Montgomery, G. W., Müller-Myhsok, B., Murphy, M. F., Neale, M. C., Nikolov, M. A., Nishita, D., Noethen, M. M., Nurnberger, J., Partonen, T., Pergadia, M. L., Reynolds, M., Ridinger, M., Rose, R. J., Rouvinen-Lagerstrom, N., Scherbaum, N., Schmael, C., Soyka, M., Stallings, M. C., Steffens, M., Treutlein, J., Tsuang, M., Wall, T. L., Wodarz, N., Yuferov, V., Zill, P., Bergen, A. W., Chen, J., Cinciripini, P. M., Edenberg, H. J., Ehringer, M. A., Ferrell, R. E., Gelernter, J., Goldman, D., Hewitt, J. K., Hopfer, C. J., Iacono, W. G., Kaprio, J., Kreek, M. J., Kremensky, I. M., Madden, P. A. F., McGue, M., Munafo, M. R., Philibert, R. A., Rietschel, M., Roy, A., Rujescu, D., Saarikoski, S. T., Swan, G. E., Todorov, A. A., Vanyukov, M. M., Weiss, R. B., Bierut, L. J., & Saccone, N. L. (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. BEHAVIOR GENETICS, 46(2), 151-169. doi:10.1007/s10519-015-9737-3.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-A743-3 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-A744-1
資料種別: 学術論文

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作成者

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 作成者:
Schwantes-An, Tae-Hwi1, 著者
Zhang, Juan1, 著者
Chen, Li-Shiun1, 著者
Hartz, Sarah M.1, 著者
Culverhouse, Robert C.1, 著者
Chen, Xiangning1, 著者
Coon, Hilary1, 著者
Frank, Josef1, 著者
Kamens, Helen M.1, 著者
Konte, Bettina1, 著者
Kovanen, Leena1, 著者
Latvala, Antti1, 著者
Legrand, Lisa N.1, 著者
Maher, Brion S.1, 著者
Melroy, Whitney E.1, 著者
Nelson, Elliot C.1, 著者
Reid, Mark W.1, 著者
Robinson, Jason D.1, 著者
Shen, Pei-Hong1, 著者
Yang, Bao-Zhu1, 著者
Andrews, Judy A.1, 著者Aveyard, Paul1, 著者Beltcheva, Olga1, 著者Brown, Sandra A.1, 著者Cannon, Dale S.1, 著者Cichon, Sven1, 著者Corley, Robin P.1, 著者Dahmen, Norbert1, 著者Degenhardt, Louisa1, 著者Foroud, Tatiana1, 著者Gaebel, Wolfgang1, 著者Giegling, Ina1, 著者Glatt, Stephen J.1, 著者Grucza, Richard A.1, 著者Hardin, Jill1, 著者Hartmann, Annette M.1, 著者Heath, Andrew C.1, 著者Herms, Stefan1, 著者Hodgkinson, Colin A.1, 著者Hoffmann, Per1, 著者Hops, Hyman1, 著者Huizinga, David1, 著者Ising, Marcus1, 著者Johnson, Eric O.1, 著者Johnstone, Elaine1, 著者Kaneva, Radka P.1, 著者Kendler, Kenneth S.1, 著者Kiefer, Falk1, 著者Kranzler, Henry R.1, 著者Krauter, Ken S.1, 著者Levran, Orna1, 著者Lucae, Susanne1, 著者Lynskey, Michael T.1, 著者Maier, Wolfgang1, 著者Mann, Karl1, 著者Martin, Nicholas G.1, 著者Mattheisen, Manuel1, 著者Montgomery, Grant W.1, 著者Müller-Myhsok, Bertram2, 著者           Murphy, Michael F.1, 著者Neale, Michael C.1, 著者Nikolov, Momchil A.1, 著者Nishita, Denise1, 著者Noethen, Markus M.1, 著者Nurnberger, John1, 著者Partonen, Timo1, 著者Pergadia, Michele L.1, 著者Reynolds, Maureen1, 著者Ridinger, Monika1, 著者Rose, Richard J.1, 著者Rouvinen-Lagerstrom, Noora1, 著者Scherbaum, Norbert1, 著者Schmael, Christine1, 著者Soyka, Michael1, 著者Stallings, Michael C.1, 著者Steffens, Michael1, 著者Treutlein, Jens1, 著者Tsuang, Ming1, 著者Wall, Tamara L.1, 著者Wodarz, Norbert1, 著者Yuferov, Vadim1, 著者Zill, Peter1, 著者Bergen, Andrew W.1, 著者Chen, Jingchun1, 著者Cinciripini, Paul M.1, 著者Edenberg, Howard J.1, 著者Ehringer, Marissa A.1, 著者Ferrell, Robert E.1, 著者Gelernter, Joel1, 著者Goldman, David1, 著者Hewitt, John K.1, 著者Hopfer, Christian J.1, 著者Iacono, William G.1, 著者Kaprio, Jaakko1, 著者Kreek, Mary Jeanne1, 著者Kremensky, Ivo M.1, 著者Madden, Pamela A. F.1, 著者McGue, Matt1, 著者Munafo, Marcus R.1, 著者Philibert, Robert A.1, 著者Rietschel, Marcella1, 著者Roy, Alec1, 著者Rujescu, Dan1, 著者Saarikoski, Sirkku T.1, 著者Swan, Gary E.1, 著者Todorov, Alexandre A.1, 著者Vanyukov, Michael M.1, 著者Weiss, Robert B.1, 著者Bierut, Laura J.1, 著者Saccone, Nancy L.1, 著者 全て表示
所属:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: Addiction, substance dependence, OPRM1, opioid receptor, single nucleotide polymorphism (SNP), genetic association
 要旨: The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, rs1799971 has on substance dependence risk, we conducted collaborative meta-analyses of 25 datasets with over 28,000 European-ancestry subjects. We investigated non-specific risk for "general" substance dependence, comparing cases dependent on any substance to controls who were non-dependent on all assessed substances. We also examined five specific substance dependence diagnoses: DSM-IV alcohol, opioid, cannabis, and cocaine dependence, and nicotine dependence defined by the proxy of heavy/light smoking (cigarettes-per-day > 20 vs. a parts per thousand currency sign10). The G allele showed a modest protective effect on general substance dependence (OR = 0.90, 95 % C.I. [0.83-0.97], p value = 0.0095, N = 16,908). We observed similar effects for each individual substance, although these were not statistically significant, likely because of reduced sample sizes. We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances. This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses.

資料詳細

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言語: eng - English
 日付: 2016-03
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000370135800001
DOI: 10.1007/s10519-015-9737-3
 学位: -

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出版物 1

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出版物名: BEHAVIOR GENETICS
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: New York, NY, USA : Springer Science+Business Media
ページ: - 巻号: 46 (2) 通巻号: - 開始・終了ページ: 151 - 169 識別子（ISBN, ISSN, DOIなど）: ISSN: 0001-8244