ausblenden:
Schlagwörter:
Fluoxetine, Neurodevelopmental disorders, impulsivity, metabolomics, fibroblasts, biomarkers
Zusammenfassung:
We report on biochemical pathways perturbed upon chronic fluoxetine
administration to juvenile macaques using global metabolomics analyses
of fibroblasts derived from skin biopsies. After exposure to tissue
culture conditions confounding environmental factors are eliminated and
identification of metabolites whose levels are affected by the drug
become apparent with a better signal-to-noise ratio compared to data
obtained from plasma and cerebrospinal fluid (CSF). Levels of more than
200 metabolites were analyzed to interrogate affected molecular pathways
and identify biomarkers of drug response. In addition, we have
correlated the metabolomics results with monoamine oxidase (MAOA)
genotype and impulsivity behavioral data. Affected pathways include
Purine and Pyrimidine metabolisms that have been previously implicated
to contribute to neuropsychiatric disorders.
