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  Cilia-based flow network in the brain ventricles.

Faubel, R., Westendorf, C., Bodenschatz, E., & Eichele, G. (2016). Cilia-based flow network in the brain ventricles. Science, 353(6295), 176-178. doi:10.1126/science.aae0450.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-FF74-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-A7A2-C
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http://science.sciencemag.org/content/353/6295/176 (Publisher version)
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 Creators:
Faubel, R.1, Author           
Westendorf, C.2, Author           
Bodenschatz, E.2, Author           
Eichele, G.1, Author           
Affiliations:
1Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society, ou_persistent34              
2Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Cerebrospinal fluid conveys many physiologically important signaling factors through the ventricular cavities of the brain. We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle. We also discovered a cilia-based switch that reliably and periodically alters the flow pattern so as to create a dynamic subdivision that may control substance distribution in the third ventricle. Complex flow patterns were also present in the third ventricles of rats and pigs. Our work suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks.

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Language(s): eng - English
 Dates: 2016-07-082016-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.aae0450
 Degree: -

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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 353 (6295) Sequence Number: - Start / End Page: 176 - 178 Identifier: -