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  Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

Albrechtsen, N. J. W., Hornburg, D., Albrechtsen, R., Svendsen, B., Torang, S., Jepsen, S. L., et al. (2016). Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine, 7, 112-120. doi:10.1016/j.ebiom.2016.03.034.

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 Creators:
Albrechtsen, Nicolai J. Wewer1, Author           
Hornburg, Daniel1, Author           
Albrechtsen, Reidar2, Author
Svendsen, Berit2, Author
Torang, Signe2, Author
Jepsen, Sara L.2, Author
Kuhre, Rune E.2, Author
Hansen, Marie2, Author
Janus, Charlotte2, Author
Floyd, Andrea2, Author
Lund, Asger2, Author
Vilsboll, Tina2, Author
Knop, Filip K.2, Author
Vestergaard, Henrik2, Author
Deacon, Carolyn F.2, Author
Meissner, Felix1, 3, Author           
Mann, Matthias1, Author           
Holst, Jens J.2, Author
Hartmann, Bolette2, Author
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              
3Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              

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Free keywords: GLUCAGON-LIKE PEPTIDE-1; LOW ABUNDANCE PROTEINS; OBESE-PATIENTS; CELLS; SECRETION; INTESTINE; HORMONE; GLP-1; PHARMACOKINETICS; QUANTIFICATIONGeneral & Internal Medicine; Gut hormones; GLP-1; Low-abundant peptides; Mass-spectrometry; Proteomics;
 Abstract: Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory peptides in humans. We demonstrate the clinical applicability of this platform by studying a hitherto neglected glucose-and appetite-regulating gut hormone, namely, oxyntomodulin. Our results show that the secretion of oxyntomodulin in patients with type 2 diabetes is significantly impaired, and that its level is increased by more than 10-fold after gastric bypass surgery. Furthermore, we report that oxyntomodulin is co-distributed and co-secreted with the insulin-stimulating and appetite-regulating gut hormone glucagon-like peptide-1 (GLP-1), is inactivated by the same protease (dipeptidyl peptidase-4) as GLP-1 and acts through its receptor. Thus, oxyntomodulin may participate with GLP-1 in the regulation of glucose metabolism and appetite in humans. In conclusion, this mass spectrometry-based platformis a powerful resource for identifying and characterizing metabolically active low-abundance peptides. (C) 2016 The Authors. Published by Elsevier B.V.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
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Title: EBioMedicine
Source Genre: Journal
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Publ. Info: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS : ELSEVIER SCIENCE BV
Pages: - Volume / Issue: 7 Sequence Number: - Start / End Page: 112 - 120 Identifier: ISSN: 2352-3964