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  A worldwide competition to compare the speed and chemotactic accuracy of neutrophil-like cells.

Skoge, M., Wong, E., Hamza, B., Bae, A., Martel, J., Kataria, R., et al. (2016). A worldwide competition to compare the speed and chemotactic accuracy of neutrophil-like cells. PLoS One, 11(6): e0154491. doi:10.1371/journal.pone.0154491.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-05AF-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-406A-C
Genre: Journal Article

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 Creators:
Skoge, M., Author
Wong, E., Author
Hamza, B., Author
Bae, Albert1, Author              
Martel, J., Author
Kataria, R., Author
Keizer-Gunnink, I., Author
Kortholt, A., Author
Van Haastert, P. J. M., Author
Charras, G., Author
Janetopoulos, C., Author
Irimia, D., Author
Affiliations:
1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Chemotaxis is the ability to migrate towards the source of chemical gradients. It underlies the ability of neutrophils and other immune cells to hone in on their targets and defend against invading pathogens. Given the importance of neutrophil migration to health and disease, it is crucial to understand the basic mechanisms controlling chemotaxis so that strategies can be developed to modulate cell migration in clinical settings. Because of the complexity of human genetics, Dictyostelium and HL60 cells have long served as models system for studying chemotaxis. Since many of our current insights into chemotaxis have been gained from these two model systems, we decided to compare them side by side in a set of winner-take-all races, the Dicty World Races. These worldwide competitions challenge researchers to genetically engineer and pharmacologically enhance the model systems to compete in microfluidic racecourses. These races bring together technological innovations in genetic engineering and precision measurement of cell motility. Fourteen teams participated in the inaugural Dicty World Race 2014 and contributed cell lines, which they tuned for enhanced speed and chemotactic accuracy. The race enabled large-scale analyses of chemotaxis in complex environments and revealed an intriguing balance of speed and accuracy of the model cell lines. The successes of the first race validated the concept of using fun-spirited competition to gain insights into the complex mechanisms controlling chemotaxis, while the challenges of the first race will guide further technological development and planning of future events.

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Language(s): eng - English
 Dates: 2016-06-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0154491
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Title: PLoS One
Source Genre: Journal
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Pages: 19 Volume / Issue: 11 (6) Sequence Number: e0154491 Start / End Page: - Identifier: -