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  Impact of attenuation correction on clinical [18F]FDG brain PET in combined PET/MRI

Werner, P., Rullmann, M., Bresch, A., Tiepolt, S., Jochimsen, T., Lobsien, D., et al. (2016). Impact of attenuation correction on clinical [18F]FDG brain PET in combined PET/MRI. EJNMMI Research, 6: 47. doi:10.1186/s13550-016-0200-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-0B58-E Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E3C9-B
Genre: Journal Article

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 Creators:
Werner, P.1, Author
Rullmann, M.1, Author
Bresch, A.1, Author
Tiepolt, S.1, Author
Jochimsen, T.1, Author
Lobsien, D.2, Author
Schroeter, Matthias L.3, 4, Author              
Sabri, O.1, Author
Barthel, H.1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: PET/MR; Attenuation correction; FDG imaging
 Abstract: Background In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anatomic MRI or proton density-weighted zero-time imaging may solve this problem in the future. However, there is an ongoing debate if the current error is acceptable for clinical use and/or research. Methods We examined this feature for [18F] fluorodeoxyglucose (FDG) brain PET in 13 patients with clinical signs of dementia or movement disorders who subsequently underwent PET/CT and PET/MRI on the same day. Multiple MR-AC approaches including a CT-derived AC were applied. Results The resulting PET data was compared to the CT-derived standard regarding the quantification error and its clinical impact. On a quantitative level, −11.9 to +2 % deviations from the CT-AC standard were found. These deviations, however, did not translate into a systematic diagnostic error. This, as overall patterns of hypometabolism (which are decisive for clinical diagnostics), remained largely unchanged. Conclusions Despite a quantitative error by the omission of bone in MR-AC, clinical quality of brain [18F]FDG is not relevantly affected. Thus, brain [18F]FDG PET can already, even now with suboptimal MR-AC, be utilized for clinical routine purposes, even though the MR-AC warrants improvement.

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Language(s): eng - English
 Dates: 2016-03-242016-05-232016-06-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s13550-016-0200-0
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Title: EJNMMI Research
Source Genre: Journal
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Publ. Info: Berlin, Germany : Springer
Pages: - Volume / Issue: 6 Sequence Number: 47 Start / End Page: - Identifier: ISSN: 2191-219X
CoNE: /journals/resource/2191-219X