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  Altered temporal dynamics of neural adaptation in the aging human auditory cortex

Herrmann, B., Henry, M., Johnsrude, I. S., & Obleser, J. (2016). Altered temporal dynamics of neural adaptation in the aging human auditory cortex. Neurobiology of Aging, 45, 10-22. doi:10.1016/j.neurobiolaging.2016.05.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-0B9D-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1D30-7
Genre: Journal Article

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 Creators:
Herrmann, Björn1, 2, Author              
Henry, Molly1, 2, Author              
Johnsrude, Ingrid S.1, 3, Author
Obleser, Jonas2, 4, Author              
Affiliations:
1Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, ON, Canada, ou_persistent22              
2Max Planck Research Group Auditory Cognition, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_751545              
3School of Communication Sciences & Disorders, University of Western Ontario, London, ON, Canada, ou_persistent22              
4Department of Psychology, University of Lübeck, Germany, ou_persistent22              

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Free keywords: Aging; Electroencephalography; Neural adaptation; Temporal context
 Abstract: Neural response adaptation plays an important role in perception and cognition. Here, we used electroencephalography to investigate how aging affects the temporal dynamics of neural adaptation in human auditory cortex. Younger (18–31 years) and older (51–70 years) normal hearing adults listened to tone sequences with varying onset-to-onset intervals. Our results show long-lasting neural adaptation such that the response to a particular tone is a nonlinear function of the extended temporal history of sound events. Most important, aging is associated with multiple changes in auditory cortex; older adults exhibit larger and less variable response magnitudes, a larger dynamic response range, and a reduced sensitivity to temporal context. Computational modeling suggests that reduced adaptation recovery times underlie these changes in the aging auditory cortex and that the extended temporal stimulation has less influence on the neural response to the current sound in older compared with younger individuals. Our human electroencephalography results critically narrow the gap to animal electrophysiology work suggesting a compensatory release from cortical inhibition accompanying hearing loss and aging.

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Language(s): eng - English
 Dates: 2016-04-112015-12-042016-05-072016-05-142016-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2016.05.006
PMID: 27459921
Other: Epub 2016
 Degree: -

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 45 Sequence Number: - Start / End Page: 10 - 22 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902