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  Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier

Azhari, H., Strauss, M., Hook, S., Boyd, B. J., & Rizwan, S. B. (2016). Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier. European Journal of Pharmaceutics and Biopharmaceutics, 104, 148-155. doi:10.1016/j.ejpb.2016.05.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1063-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1064-F
Genre: Journal Article

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 Creators:
Azhari, Hanisah1, Author
Strauss, Mike2, Author              
Hook, Sarah1, Author
Boyd, Ben J.1, Author
Rizwan, Shakila B.1, Author
Affiliations:
1external, ou_persistent22              
2Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565170              

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Free keywords: DRUG TRANSPORT; NANOPARTICLE DISPERSIONS; SUBMICRON PARTICLES; ALZHEIMERS-DISEASE; STERIC STABILIZERS; CONTROLLED-TRIAL; PHASE-BEHAVIOR; IN-VITRO; PHYTANTRIOL; F127Cubosomes; Tween 80; Pluronic F127; Phytantriol; Blood -brain barrier; Cryogenic electron tomography (cryo-ET);
 Abstract: Coating nanoparticles with the surfactant Tween 80 have been previously shown to enhance drug delivery across the blood brain barrier (BBB). The aim of this study was to investigate whether Tween 80 could be used to stabilise phytantriol-based cubosomes thereby enabling potential application in delivering macromolecular therapeutics to the brain. Cubosome particles with their large internal and external surface area by virtue of their nanostructure are ideal for delivery of macromolecules. Phase behaviour studies were conducted using a combination of optical microscopy and small-angle X-ray scattering (SAXS) and the addition of Tween 80 to mixtures of phytantriol and water resulted in a rich array of lyotropic mesophases. In particular, a large cubic phase region and a two-phase region of readily dispersed cubosomes is observed. Cubosomes with different concentrations of Tween 80 and phytantriol as the liquid crystal forming lipid were prepared using the solvent precursor method and their physical properties were investigated. A combination of dynamic light scattering, cryogenic electron tomography and SAXS shows formation of well-defined cubosomes with a narrow size distribution and the Im3m cubic structure. Collectively, the results confirm that Tween 80 can effectively stabilize phytantriol cubosomes, opening the possibility for future application in drug delivery across the BBB. Moreover, well-defined, homogenous cubosome formulations prepared using the mild solvent precursor dilution method has significant implications for large-scale production of cubosomes, which currently is a major barrier to the application of cubosomes in the clinic. (C) 2016 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: European Journal of Pharmaceutics and Biopharmaceutics
  Other : Eur. J. Pharm. Biopharm.
Source Genre: Journal
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Publ. Info: Stuttgart : Elsevier
Pages: - Volume / Issue: 104 Sequence Number: - Start / End Page: 148 - 155 Identifier: ISSN: 0939-6411
CoNE: https://pure.mpg.de/cone/journals/resource/954928567575