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  A complementary role of intracortical inhibition in age-related tactile degradation and its remodelling in humans

Pleger, B., Wilimzig, C., Nicolas, V., Kalisch, T., Ragert, P., Tegenthoff, M., et al. (2016). A complementary role of intracortical inhibition in age-related tactile degradation and its remodelling in humans. Scientific Reports, 6: 27388. doi:10.1038/srep27388.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-108C-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1DEC-4
Genre: Journal Article

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 Creators:
Pleger, Burkhard1, 2, 3, Author              
Wilimzig, Claudia4, Author
Nicolas, Volkmar5, Author
Kalisch, Tobias4, Author
Ragert, Patrick3, Author              
Tegenthoff, Martin1, Author
Dinse, Hubert R.1, 4, Author
Affiliations:
1Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Neural Plasticity Lab, Institute for Neuroinformatics, Ruhr University, Bochum, Germany, ou_persistent22              
5Department of Radiology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              

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 Abstract: Many attempts are currently underway to restore age-related degraded perception, however, the link between restored perception and remodeled brain function remains elusive. To understand remodeling of age-related cortical reorganization we combined functional magnetic resonance imaging (fMRI) with assessments of tactile acuity, perceptual learning, and computational modeling. We show that aging leads to tactile degradation parallel to enhanced activity in somatosensory cortex. Using a neural field model we reconciled the empirical age-effects by weakening of cortical lateral inhibition. Using perceptual learning, we were able to partially restore tactile acuity, which however was not accompanied by the expected attenuation of cortical activity, but by a further enhancement. The neural field model reproduced these learning effects solely through a weakening of the amplitude of inhibition. These findings suggest that the restoration of age-related degraded tactile acuity on the cortical level is not achieved by re-strengthening lateral inhibition but by further weakening intracortical inhibition.

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Language(s): eng - English
 Dates: 2015-04-172016-05-132016-06-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/srep27388
PMID: 27302219
PMC: PMC4908433
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 27388 Start / End Page: - Identifier: Other: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322