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  Affective responses across psychiatric disorders: A dimensional approach

Hägele, C., Friedel, E., Schlagenhauf, F., Sterzer, P., Beck, A., Bermpohl, F., et al. (2016). Affective responses across psychiatric disorders: A dimensional approach. Neuroscience Letters, 623, 71-78. doi:10.1016/j.neulet.2016.04.037.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-10CE-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1A5A-C
Genre: Journal Article

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 Creators:
Hägele, Claudia1, Author
Friedel, Eva1, Author
Schlagenhauf, Florian1, 2, Author              
Sterzer, Philipp1, 3, Author
Beck, Anne1, Author
Bermpohl, Felix1, 3, Author
Stoy, Meline1, Author
Held-Poschardt, Dada1, Author
Wittmann, André1, Author
Ströhle, Andreas1, 3, Author
Heinz, Andreas1, 3, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Dimensional; fMRI; Emotional pictures task; IAPS; Connectivity
 Abstract: Studying psychiatric disorders across nosological boundaries aims at a better understanding of mental disorders by identifying comprehensive signatures of core symptoms. Here, we studied neurobiological correlates of emotion processing in several major psychiatric disorders. We assessed differences between diagnostic groups, and investigated whether there is a psychopathological correlate of emotion processing that transcends disorder categories. 135 patient with psychiatric disorders (alcohol dependence, n = 29; schizophrenia, n = 37; major depressive disorder (MDD), n = 25; acute manic episode of bipolar disorder, n = 12; panic disorder, n = 12, attention deficit/hyperactivity disorder (ADHD), n = 20) and healthy controls (n = 40) underwent an functional magnetic resonance imaging (fMRI) experiment with affectively positive, aversive and neutral pictures from the International Affective Picture System (IAPS). Between-group differences were assessed with full-factorial ANOVAs, with age, gender and smoking habits as covariates. Self-ratings of depressed mood and anxiety were correlated with activation clusters showing significant stimulus-evoked fMRI activation. Furthermore, we examined functional connectivity with the amygdala as seed region during the processing of aversive pictures. During the presentation of pleasant stimuli, we observed across all subjects significant activation of the ventromedial prefrontal cortex (vmPFC), bilateral middle temporal gyrus and right precuneus, while a significant activation of the left amygdala and the bilateral middle temporal gyrus was found during the presentation of aversive stimuli. We did neither find any significant interaction with diagnostic group, nor any correlation with depression and anxiety scores at the activated clusters or with amygdala connectivity. Positive and aversive IAPS-stimuli were consistently processed in limbic and prefrontal brain areas, irrespective of diagnostic category. A dimensional correlate of these neural activation patterns was not found.

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Language(s): eng - English
 Dates: 2016-04-072015-10-092016-04-152016-04-262016-06-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neulet.2016.04.037
PMID: 27130821
Other: Epub 2016
 Degree: -

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Title: Neuroscience Letters
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 623 Sequence Number: - Start / End Page: 71 - 78 Identifier: ISSN: 0304-3940
CoNE: /journals/resource/954925512448