English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [11C] DASB positron emission tomography study

Hesse, S., Rullmann, M., Luthardt, J., Winter, K., Hankir, M. K., Becker, G.-A., et al. (2016). Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [11C] DASB positron emission tomography study. European Journal of Nuclear Medicine and Molecular Imaging, 43(6), 1096-1104. doi:10.1007/s00259-015-3243-y.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-15EF-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1D33-4
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hesse, Swen1, 2, Author
Rullmann, Michael1, 2, 3, Author              
Luthardt, Julia1, Author
Winter, Karsten4, 5, Author
Hankir, Mohammed K.2, Author
Becker, Georg-Alexander1, Author
Zientek, Franziska2, Author
Reissig, Georg2, Author
Regenthal, Ralf6, Author
Drabe, Mandy2, Author
Schinke, Christian7, Author
Bresch, Anke1, Author
Arélin, Katrin3, 8, Author              
Lobsien, Donald9, Author
Patt, Marianne1, Author
Meyer, Philipp M.10, Author
Fasshauer, Mathias2, 11, Author
Fenske, Wiebke K.2, 11, Author
Blüher, Matthias10, 11, Author
Stumvoll, Michael2, 11, Author
Sabri, Osama1, 2, Author more..
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Germany, ou_persistent22              
5Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
6Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig, Germany, ou_persistent22              
7Department of Neurology, University of Leipzig, Germany, ou_persistent22              
8Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
9Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
10Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
11Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Serotonin; Serotonin transporter; Positron emission tomography (PET); Obesity; Body mass index (BMI); Depression
 Abstract: Purpose The role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of human obesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies of central 5-HTT availability have been inconsistent, which is thought to be brought about mainly by the low number of individuals with a high body mass index (BMI) previously used. The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls. Methods We performed PET using the 5-HTT selective radiotracer [11C] DASB on 30 highly obese (BMI range between 35 and 55 kg/m2) and 15 age- and sex-matched non-obese volunteers (BMI range between 19 and 27 kg/m2) in a cross-sectional study design. The 5-HTT binding potential (BPND) was used as the outcome parameter. Results On a group level, there was no significant difference in 5-HTT BPND in various cortical and subcortical regions in individuals with the highest BMI compared with non-obese controls, while statistical models showed minor effects of age, sex, and the degree of depression on 5-HTT BPND. Conclusion The overall finding of a lack of significantly altered 5-HTT availability together with its high variance in obese individuals justifies the investigation of individual behavioral responses to external and internal cues which may further define distinct phenotypes and subgroups in human obesity.

Details

show
hide
Language(s): eng - English
 Dates: 2015-08-062015-10-152015-11-182016-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00259-015-3243-y
PMID: 26577939
Other: Epub 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: 43 (6) Sequence Number: - Start / End Page: 1096 - 1104 Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624