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  The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation

Vucicevic, D., Gehre, M., Dhamija, S., Friis-Hansen, L., Meierhofer, D., Sauer, S., et al. (2016). The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation. Oncotarget, 7(23), 33934-33947. doi:10.18632/oncotarget.8985.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-16DD-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1730-7
Genre: Journal Article

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Vučićević.pdf (Publisher version), 8MB
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@ 2016 Impact Journals, LLC

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 Creators:
Vucicevic, Dubravka1, Author              
Gehre, Maja1, Author              
Dhamija, Sonam, Author
Friis-Hansen, Lennart, Author
Meierhofer, David2, Author              
Sauer, Sascha, Author
Ørom, Ulf Andersson1, Author              
Affiliations:
1Long non-coding RNA (Ulf Andersson Ørom), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479659              
2Mass Spectrometry (Head: David Meierhofer), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479669              

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Free keywords: MYC, long ncRNA
 Abstract: Long non-coding RNAs are important regulators of gene expression and signaling pathways. The expression of long ncRNAs is dysregulated in cancer and other diseases. The identification and characterization of long ncRNAs is often challenging due to their low expression level and localization to chromatin. Here, we identify a functional long ncRNA, PARROT (Proliferation Associated RNA and Regulator Of Translation) transcribed by RNA polymerase II and expressed at a relatively high level in a number of cell lines. The PARROT long ncRNA is associated with proliferation in both transformed and normal cell lines. We characterize the long ncRNA PARROT as an upstream regulator of c-Myc affecting cellular proliferation and translation using RNA sequencing and mass spectrometry following depletion of the long ncRNA. PARROT is repressed during senescence of human mammary epithelial cells and overexpressed in some cancers, suggesting an important association with proliferation through regulation of c-Myc. With this study, we add to the knowledge of cytoplasmic functional long ncRNAs and extent the long ncRNA-Myc regulatory network in transformed and normal cells.

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 Dates: 2016-04-252016-07
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.18632/oncotarget.8985
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Title: Oncotarget
Source Genre: Journal
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Pages: - Volume / Issue: 7 (23) Sequence Number: - Start / End Page: 33934 - 33947 Identifier: -