English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment

Köbe, T., Witte, V., Schnelle, A., Lesemann, A., Fabian, S., Tesky, V. A., et al. (2016). Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. NeuroImage, 131, 226-238. doi:10.1016/j.neuroimage.2015.09.050.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Köbe, Theresa1, 2, Author
Witte, Veronica1, 2, 3, 4, Author           
Schnelle, Ariane1, 2, Author
Lesemann, Anne1, 2, Author
Fabian, Sonja1, 2, Author
Tesky, Valentina A.5, Author
Pantel, Johannes5, Author
Flöel, Agnes1, 2, 6, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, ou_persistent22              
5Institute of General Practice, Goethe University, Frankfurt, Germany, ou_persistent22              
6Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: Cognition; Combined intervention; MCI; Randomized controlled trial; Voxel-based morphometry
 Abstract: Previous studies in older adults suggested beneficial effects of omega-3 fatty acid (FA) supplementation, aerobic exercise, or cognitive stimulation on brain structure and function. However, combined effects of these interventions in patients suffering from mild cognitive impairment (MCI) are unknown. Using a randomized interventional design, we evaluated the effect of combined omega-3 FA supplementation, aerobic exercise and cognitive stimulation (target intervention) versus omega-3 FA supplementation and non-aerobic exercise (control intervention) on cognitive function and gray matter volume in patients with MCI. Moreover, we analyzed potential vascular, metabolic or inflammatory mechanisms underlying these effects. Twenty-two MCI patients (8 females; 60–80 years) successfully completed six months of omega-3 FA intake, aerobic cycling training and cognitive stimulation (n = 13) or omega-3 FA intake and non-aerobic stretching and toning (n = 9). Before and after the interventions, cognitive performance, magnetic resonance imaging of the brain at 3 T (n = 20), intima-media thickness of the internal carotid artery and serum markers of glucose control, lipid and B-vitamin metabolism, and inflammation were assessed. Intervention-related changes in gray matter volume of Alzheimer's disease (AD)-related brain regions, i.e., frontal, parietal, temporal and cingulate cortex were examined using voxel-based morphometry of high resolution T1-weighted images. After the intervention period, significant differences emerged in brain structure between groups: Gray matter volume decreased in the frontal, parietal and cingulate cortex of patients in the control intervention, while gray matter volume in these areas was preserved or even increased after the target intervention. Decreases in homocysteine levels in the target intervention group were associated with increases in gray matter volume in the middle frontal cortex (p = 0.010). No significant differences in cognitive performance or other vascular, metabolic and inflammatory parameters were observed between groups. This pilot study provides preliminary evidence that omega-3 FA intake combined with aerobic exercise and cognitive stimulation prevents atrophy in AD-related brain regions in MCI patients, compared to omega-3 FA intake plus the control condition of stretching and toning. These promising findings should now be validated in a larger interventional trial.

Details

show
hide
Language(s): eng - English
 Dates: 2015-08-212015-09-222015-10-012016-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.09.050
PMID: 26433119
Other: Epub 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 131 Sequence Number: - Start / End Page: 226 - 238 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166