English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  In-vivo serotonin transporter availability and somatization in healthy subjects

Bresch, A., Rullmann, M., Luthardt, J., Arélin, K., Becker, G. A., Patt, M., et al. (2016). In-vivo serotonin transporter availability and somatization in healthy subjects. Personality and Individual Differences, 94, 354-359. doi:10.1016/j.paid.2016.01.042.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1981-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1D9F-B
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Bresch, Anke1, Author
Rullmann, Michael1, 2, Author
Luthardt, Julia1, Author
Arélin, Katrin3, 4, Author              
Becker, Georg A.1, Author
Patt, Marianne1, Author
Lobsien, Donald5, Author
Baldofski, Sabrina2, Author
Drabe, Mandy1, Author
Zeisig, Vilia1, Author
Regenthal, Ralf6, Author
Blüher, Matthias7, 8, Author
Hilbert, Anja2, 9, Author
Sabri, Osama1, 2, Author
Hesse, Swen1, 2, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
6Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig, ou_persistent22              
7Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
8Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
9Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Somatization; Serotonin transporter (SERT); PET; Somatization; Healthy subjects; Symptom Checklist 90 Revised (SCL-90-R)
 Abstract: Dysregulation of the central serotonergic system is implicated in somatization, which can lead to manifest mental disease. However, neuroimaging studies on serotonin transporter (SERT) availability and somatoform symptoms as assessed by the Symptom Checklist 90 Revised (SCL-90-R) are sparse and reveal inconsistent results. The aim of this study was to explore for the first time the relationship between SERT and somatoform symptom expression in healthy volunteers including the analysis of the SERT-LPR genotype. Fourteen healthy subjects (age 36.07 ± 7.22 years, 9 females) completed the SCL-90-R, underwent [11C]DASB PET and were genotyped on the same day. SERT binding potentials (BPND) were quantified with the multilinear reference tissue model (MRI coregistration). The BPND of the right orbitofrontal cortex (OFC) correlated positively with the somatization subscale. The SERT availability of the right OFC correlated significantly with the obsessive–compulsive subscale and the degree of anxiety was associated with the BPND of the right hippocampus. No main genotype effect on regional SERT availability or on the association between SERT BPND and the respective SCL-90-R subscales was observed. Our findings document a positive correlation between frontal SERT availability and the severity of somatoform symptoms prior to the onset of disease.

Details

show
hide
Language(s): eng - English
 Dates: 2015-12-252015-09-272016-01-252016-02-112016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.paid.2016.01.042
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Personality and Individual Differences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 94 Sequence Number: - Start / End Page: 354 - 359 Identifier: ISSN: 0191-8869
CoNE: https://pure.mpg.de/cone/journals/resource/0191-8869