English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence

Garbusow, M., Schad, D., Sebold, M., Friedel, E., Bernhardt, N., Koch, S. P., et al. (2016). Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence. Addiction Biology, 21(3), 719-731. doi:10.1111/adb.12243.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1987-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19C8-0
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Garbusow, Maria1, Author
Schad, Daniel1, Author
Sebold, Miriam1, Author
Friedel, Eva1, Author
Bernhardt, Nadine2, 3, Author
Koch, Stefan P.1, Author
Steinacher, Bruno4, Author
Kathmann, Norbert5, Author
Geurts, Dirk E. M.6, 7, Author
Sommer, Christian2, Author
Müller, Dirk K.2, 3, Author
Nebe, Stephan2, 3, Author
Paul, Sören8, Author
Wittchen, Hans-Ulrich8, Author
Zimmermann, Ulrich S.2, Author
Walter, Henrik1, Author
Smolka, Michael N.2, 3, Author
Sterzer, Philipp1, Author
Rapp, Michael A.9, Author
Huys, Quentin J. M.10, 11, Author
Schlagenhauf, Florian1, 12, Author              Heinz, Andreas1, Author more..
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              
3Neuroimaging Center, TU Dresden, Germany, ou_persistent22              
4Department of Psychiatry, Psychotherapy, and Psychosomatics, Vivantes Hospitals, Berlin, Germany, ou_persistent22              
5Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
6Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
7Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
8Institute of Clinical Psychology and Psychotherapy, TU Dresden, Germany, ou_persistent22              
9Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
10Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Zurich, Switzerland, ou_persistent22              
11Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
12Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

Content

show
hide
Free keywords: Human Pavlovian-to-instrumental transfer; Nucleus accumbens; Relapse in alcohol use disorder
 Abstract: In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n = 31 detoxified patients diagnosed with alcohol dependence and n = 24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.

Details

show
hide
Language(s): eng - English
 Dates: 2015-04-012016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/adb.12243
PMID: 25828702
Other: Epub 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Addiction Biology
  Other : Addict. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 21 (3) Sequence Number: - Start / End Page: 719 - 731 Identifier: ISSN: 1355-6215
CoNE: /journals/resource/954925277561