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  16p11.2 Locus modulates response to satiety before the onset of obesity

Maillard, A. M., Hippolyte, L., Rodriguez-Herreros, B., Chawner, S. J. R. A., Dremmel, D., Agüera, Z., et al. (2016). 16p11.2 Locus modulates response to satiety before the onset of obesity. International Journal of Obesity, 40(5), 870-876. doi:10.1038/ijo.2015.247.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-19D3-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1BDA-A
Genre: Journal Article


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Maillard, A. M.1, Author
Hippolyte, L.1, Author
Rodriguez-Herreros, B.1, 2, Author
Chawner, S. J. R. A.3, Author
Dremmel, D.4, Author
Agüera, Z.5, 6, Author
Fagundo, A. B.5, 6, Author
Pain, A.1, Author
Martin-Brevet, S.1, 2, Author
Hilbert, A.7, Author
Kurz, S.4, Author
Etienne, R.1, Author
Draganski, Bogdan2, 8, Author              
Jimenez-Murcia, S.5, 6, 9, Author
Männik, K.10, 11, Author
Metspalu, A.10, Author
Reigo, A.10, Author
Isidor, B.12, Author
Le Caignec, C.12, 13, Author
David, A.12, Author
Mignot, C.14, 15, 16, AuthorKeren, B.17, Author16p11.2 European Consortium, Author              van den Bree, M. B. M.3, AuthorMunsch, S.4, AuthorFernandez-Aranda, F.5, 6, 9, AuthorBeckmann, J. S.1, 18, AuthorReymond, A.11, AuthorJacquemont, S.1, Author more..
1Service of Medical Genetics, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom, ou_persistent22              
4Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Switzerland, ou_persistent22              
5Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain, ou_persistent22              
6Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
9Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Spain, ou_persistent22              
10Estonian Genome Center, Tartu University Hospital, Estonia, ou_persistent22              
11Center for Integrative Genomics, University of Lausanne, Switzerland, ou_persistent22              
12Service de Génétique Médicale, Centre hospitalier universitaire (CHU) de Nantes, France, ou_persistent22              
13Faculté de Médecine, Institut national de la santé et de la recherche médicale, Nantes, France, ou_persistent22              
14Unité Fonctionnelle de Génétique Clinique, Département de Génétique et de Cytogénétique, Hôpital de la Salpêtrière, Paris, France, ou_persistent22              
15Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France, ou_persistent22              
16Groupe de Recherche Clinique Déficience Intellectuelle et Autisme, Université Pierre et Marie Curie-Paris, France, ou_persistent22              
17Département de Génétique et de Cytogénétique, Hôpital de la Salpêtrière, Paris, France, ou_persistent22              
18Swiss Institute of Bioinformatics, University of Lausanne, Switzerland, ou_persistent22              


Free keywords: -
 Abstract: Background: The 600 kb BP4-BP5 copy number variants (CNVs) at the 16p11.2 locus have been associated with a range of neurodevelopmental conditions including autism spectrum disorders and schizophrenia. The number of genomic copies in this region is inversely correlated with body mass index (BMI): the deletion is associated with a highly penetrant form of obesity (present in 50% of carriers by the age of 7 years and in 70% of adults), and the duplication with being underweight. Mechanisms underlying this energy imbalance remain unknown. Objective: This study aims to investigate eating behavior, cognitive traits and their relationships with BMI in carriers of 16p11.2 CNVs. Methods: We assessed individuals carrying a 16p11.2 deletion or duplication and their intrafamilial controls using food-related behavior questionnaires and cognitive measures. We also compared these carriers with cohorts of individuals presenting with obesity, binge eating disorder or bulimia. Results: Response to satiety is gene dosage-dependent in pediatric CNV carriers. Altered satiety response is present in young deletion carriers before the onset of obesity. It remains altered in adolescent carriers and correlates with obesity. Adult deletion carriers exhibit eating behavior similar to that seen in a cohort of obesity without eating disorders such as bulimia or binge eating. None of the cognitive measures are associated with eating behavior or BMI. Conclusions: These findings suggest that abnormal satiety response is a strong contributor to the energy imbalance in 16p11.2 CNV carriers, and, akin to other genetic forms of obesity, altered satiety responsiveness in children precedes the increase in BMI observed later in adolescence.


Language(s): eng - English
 Dates: 2015-11-062015-08-242015-11-162015-12-222016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/ijo.2015.247
PMID: 26620891
Other: Epub 2015
 Degree: -



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Source 1

Title: International Journal of Obesity
  Other : Int. J. Obes.
Source Genre: Journal
Publ. Info: -
Pages: - Volume / Issue: 40 (5) Sequence Number: - Start / End Page: 870 - 876 Identifier: ISSN: 0307-0565
CoNE: https://pure.mpg.de/cone/journals/resource/954925515513_1