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  Basal ganglia and cerebellar interconnectivity within the human thalamus

Pelzer, E. A., Melzer, C., Timmermann, L., von Cramon, D. Y., & Tittgemeyer, M. (2017). Basal ganglia and cerebellar interconnectivity within the human thalamus. Brain Structure & Function, 222(1), 381-392. doi:10.1007/s00429-016-1223-z.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-19ED-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C59B-0
Genre: Journal Article

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 Creators:
Pelzer, Esther A.1, 2, Author
Melzer, Corina1, Author
Timmermann, Lars2, Author
von Cramon, D. Yves1, 3, Author              
Tittgemeyer, Marc1, Author
Affiliations:
1Translational Neurocirciutry Group, Max Planck Institute for Metabolism Research, Cologne, Germany, ou_persistent22              
2Department of Neurology, University Hospital Cologne, Germany, ou_persistent22              
3Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634563              

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Free keywords: Cerebellum; Basal ganglia; Thalamus; Connectivity; Diffusion MRI; Hemispheric lateralization
 Abstract: Basal ganglia and the cerebellum are part of a densely interconnected network. While both subcortical structures process information in basically segregated loops that primarily interact in the neocortex, direct subcortical interaction has been recently confirmed by neuroanatomical studies using viral transneuronal tracers in non-human primate brains. The thalamus is thought to be the main relay station of both projection systems. Yet, our understanding of subcortical basal ganglia and cerebellar interconnectivity within the human thalamus is rather sparse, primarily due to limitation in the acquisition of in vivo tracing. Consequently, we strive to characterize projections of both systems and their potential overlap within the human thalamus by diffusion MRI and tractography. Our analysis revealed a decreasing anterior-to-posterior gradient for pallido-thalamic connections in: (1) the ventral-anterior thalamus, (2) the intralaminar nuclei, and (3) midline regions. Conversely, we found a decreasing posterior-to-anterior gradient for dentato-thalamic projections predominantly in: (1) the ventral-lateral and posterior nucleus; (2) dorsal parts of the intralaminar nuclei and the subparafascicular nucleus, and (3) the medioventral and lateral mediodorsal nucleus. A considerable overlap of connectivity pattern was apparent in intralaminar nuclei and midline regions. Notably, pallidal and cerebellar projections were both hemispherically lateralized to the left thalamus. While strikingly consistent with findings from transneuronal studies in non-human primates as well as with pre-existing anatomical studies on developmentally expressed markers or pathological human brains, our assessment provides distinctive connectional fingerprints that illustrate the anatomical substrate of integrated functional networks between basal ganglia and the cerebellum. Thereby, our findings furnish useful implications for cerebellar contributions to the clinical symptomatology of movement disorders. © 2016 The Author(s)

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Language(s): eng - English
 Dates: 2015-08-222016-04-032016-04-182017-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-016-1223-z
PMC: 27089884
PMC: PMC5225161
Other: Epub 2016
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Project name : Basal-Ganglia-Cortex-Loops: Mechanisms of Pathological Interactions and Therapeutic Modulation / KFO 219
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Funding organization : German Research Foundation (DFG)
Project name : -
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Funding program : -
Funding organization : Max Planck Society
Project name : Transregional Collaborative Research Centre 134
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 222 (1) Sequence Number: - Start / End Page: 381 - 392 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653