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  TS-EUROTRAIN: A European-wide investigation and training network on the etiology and pathophysiology of Gilles de la Tourette syndrome

Forde, N. J., Kanaan, A. S., Widomska, J., Padmanabhuni, S. S., Nespoli, E., Alexander, J., et al. (2016). TS-EUROTRAIN: A European-wide investigation and training network on the etiology and pathophysiology of Gilles de la Tourette syndrome. Frontiers in Neuroscience, 10: 384. doi:10.3389/fnins.2016.00384.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1B3F-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E3BC-A
Genre: Journal Article

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 Creators:
Forde, Natalie J.1, 2, Author
Kanaan, Ahmad S.3, 4, Author              
Widomska, Joanna2, Author
Padmanabhuni, Shanmukha S5, Author
Nespoli, Ester6, 7, Author
Alexander, John5, Author
Arranz, Juan I. Rodriguez8, Author
Fan, Siyan9, 10, 11, Author
Houssari, Rayan8, Author
Nawaz, Muhammad S.12, 13, Author
Zilhão, Nuno R.9, 14, Author
Pagliaroli, Luca15, 16, Author
Rizzo, Francesca7, 17, Author
Aranyi, Tamas16, 18, Author
Barta, Csaba15, Author
Boeckers, Tobias M17, Author
Boomsma, Dorret I.14, 19, Author
Buisman, Wim R.20, Author
Buitelaar, Jan K.2, 21, Author
Cath, Danielle9, Author
Dietrich, Andrea1, AuthorDriessen, Nicole2, AuthorDrineas, Petros22, AuthorDunlap, Michell23, AuthorGerasch, Sarah3, AuthorGlennon, Jeffrey2, AuthorHengerer, Bastian6, Authorvan den Heuvel, Odile A.10, 11, AuthorJespersgaard, Cathrine8, AuthorMöller, Harald E.4, Author              Müller-Vahl, Kirsten R.3, AuthorOpenneer, Thaïra1, AuthorPoelmans, Geert2, 24, 25, AuthorPouwels, Petra J. W.26, AuthorScharf, Jeremiah M.27, AuthorStefansson, Hreinn12, AuthorTümer, Zeynep8, AuthorVeltman, Dick10, Authorvan der Werf, Ysbrand D.11, AuthorHoekstra, Pieter J.1, AuthorLudolph, Andrea7, AuthorPaschou, Peristera5, Author more..
Affiliations:
1Department of Psychiatry, University Medical Center Groningen, the Netherlands, ou_persistent22              
2Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Psychiatry, Social psychiatry and Psychotherapy, Hannover Medical School MHH, Germany, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634558              
5Department of Molecular Biology and Genetics, Democritus University of Thrace, Greece, ou_persistent22              
6CNS Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Hannover, Germany, ou_persistent22              
7Department of Child and Adolescent Psychiatry, Ulm University, Germany, ou_persistent22              
8Center for Applied Human Molecular Genetics, Kennedy Center, Glostrup, Denmark, ou_persistent22              
9Department of Psychology, Utrecht University, the Netherlands, ou_persistent22              
10Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
11Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
12deCODE Genetics Inc., Reykjavik, Iceland, ou_persistent22              
13Faculty of Medicine, University of Iceland, Reykjavik, Iceland, ou_persistent22              
14Department of Biological Psychology, VU University Amsterdam, the Netherlands, ou_persistent22              
15Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary, ou_persistent22              
16Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, ou_persistent22              
17Institute for Anatomy and Cell Biology, Ulm University, Germany, ou_persistent22              
18University of Angers, France, ou_persistent22              
19EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
20Stichting Gilles de la Tourette, Rhoon, the Netherlands, ou_persistent22              
21Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
22Rensselaer Polytechnic Institute, Troy, NY, USA, ou_persistent22              
23Tourette-Gesellschaft Deutschland e.V., Hannover, Germany, ou_persistent22              
24Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
25Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
26Department of Physics & Medical Technology, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
27Departments of Psychiatry and Neurology, Harvard Medical School, Boston, MA, USA, ou_persistent22              

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Free keywords: Initial training netwok; Gilles de la Tourette syndrome; Tourette Disorder; Aetiology; Genetics; Neuroimaging; Animal Models
 Abstract: Gilles de la Tourette Syndrome (GTS) is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared aetiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No.316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex aetiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared aetiology between GTS, OCD and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and twelve PhD candidates pursue the project. Our ultimate aims are to elucidate the complex aetiology and neurobiological underpinnings of GTS, translate research findings into clinical applications and establish Pan-European infrastructure for the study of GTS and associated disorders.

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Language(s): eng - English
 Dates: 2016-03-162016-08-082016-08-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fnins.2016.00384
 Degree: -

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 384 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548