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  Cellular Homeostasis and Aging

Hartl, F. U. (2016). Cellular Homeostasis and Aging. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85, 85, 1-4. doi:10.1146/annurev-biochem-011116-110806.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-1EAE-C Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-1EB0-4
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 Urheber:
Hartl, F. Ulrich1, Autor           
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Schlagwörter: C-ELEGANS; PROTEIN; PROTEOSTASIS; DISEASE; STRESS; AGGREGATION; EVENTprotein homeostasis; proteostasis; insulin signaling; dietary restriction; oxidative stress;
 Zusammenfassung: Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during aging leads to dysfunction of specific cell types and tissues, rendering the organism susceptible to a range of chronic diseases. This volume of the Annual Review of Biochemistry contains a set of two reviews addressing our current understanding of the molecular mechanisms underlying aging in model organisms and humans.

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Sprache(n): eng - English
 Datum: 2016
 Publikationsstatus: Erschienen
 Seiten: 4
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000379324700002
DOI: 10.1146/annurev-biochem-011116-110806
 Art des Abschluß: -

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Titel: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85
  Alternativer Titel : Annu. Rev. Biochem..
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA : ANNUAL REVIEWS
Seiten: - Band / Heft: 85 Artikelnummer: - Start- / Endseite: 1 - 4 Identifikator: ISSN: 0066-4154
ISBN: 978-0-8243-0885-8