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  Thyroid Cells Exposed to Simulated Microgravity Conditions - Comparison of the Fast Rotating Clinostat and the Random Positioning Machine

Warnke, E., Kopp, S., Wehland, M., Hemmersbach, R., Bauer, J., Pietsch, J., et al. (2016). Thyroid Cells Exposed to Simulated Microgravity Conditions - Comparison of the Fast Rotating Clinostat and the Random Positioning Machine. Microgravity Science and Technology, 28(3), 247-260. doi:10.1007/s12217-015-9456-7.

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 Creators:
Warnke, Elisabeth1, Author
Kopp, Sascha1, Author
Wehland, Markus1, Author
Hemmersbach, Ruth1, Author
Bauer, Johann2, Author              
Pietsch, Jessica1, Author
Infanger, Manfred1, Author
Grimm, Daniela1, Author
Affiliations:
1external, ou_persistent22              
2Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565170              

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Free keywords: SPHEROID FORMATION; CANCER CELLS; FOLLICULAR CELLS; SIGNALING PATHWAYS; EPITHELIAL-CELLS; GENE-EXPRESSION; CARCINOMA CELLS; SPACE; GRAVITY; APOPTOSISThyroid cells; Simulated microgravity; Random Positioning Machine; Clinostat; Cytokines; Spheroids;
 Abstract: The ground-based facilities 2D clinostat (CN) and Random Positioning Machine (RPM) were designed to simulate microgravity conditions on Earth. With support of the CORA-ESA-GBF program we could use both facilities to investigate the impact of simulated microgravity on normal and malignant thyroid cells. In this review we report about the current knowledge of thyroid cancer cells and normal thyrocytes grown under altered gravity conditions with a special focus on growth behaviour, changes in the gene expression pattern and protein content, as well as on altered secretion behaviour of the cells. We reviewed data obtained from normal thyrocytes and cell lines (two poorly differentiated follicular thyroid cancer cell lines FTC-133 and ML-1, as well as the normal thyroid cell lines Nthy-ori 3-1 and HTU-5). Thyroid cells cultured under conditions of simulated microgravity (RPM and CN) and in Space showed similar changes with respect to spheroid formation. In static 1g control cultures no spheroids were detectable. Changes in the regulation of cytokines are discussed to be involved in MCS (multicellular spheroids) formation. The ESA-GBF program helps the scientists to prepare future spaceflight experiments and furthermore, it might help to identify targets for drug therapy against thyroid cancer.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000379321900007
DOI: 10.1007/s12217-015-9456-7
 Degree: -

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Title: Microgravity Science and Technology
  Abbreviation : Microgravity Sci. Technol.
Source Genre: Journal
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Publ. Info: Springer International Publishing AG
Pages: - Volume / Issue: 28 (3) Sequence Number: - Start / End Page: 247 - 260 Identifier: ISSN: 0938-0108
CoNE: https://pure.mpg.de/cone/journals/resource/0938-0108