English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Multimodal correlative investigation of the interplaying micro-architecture, chemical composition and mechanical properties of human cortical bone tissue reveals predominant role of fibrillar organization in determining microelastic tissue properties

Schrof, S., Varga, P., Hesse, B., Schöne, M., Schütz, R., Masic, A., et al. (2016). Multimodal correlative investigation of the interplaying micro-architecture, chemical composition and mechanical properties of human cortical bone tissue reveals predominant role of fibrillar organization in determining microelastic tissue properties. Acta Biomaterialia, 44, 51-64. doi:10.1016/j.actbio.2016.08.001.

Item is

Files

show Files
hide Files
:
2327616.pdf (Publisher version), 4MB
 
File Permalink:
-
Name:
2327616.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Manuskript.pdf (Any fulltext), 4MB
 
File Permalink:
-
Name:
Manuskript.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Schrof, Susanne, Author
Varga, Peter, Author
Hesse, Bernhard, Author
Schöne, Martin, Author
Schütz, Roman1, Author           
Masic, Admir, Author
Raum, Kay, Author
Affiliations:
1Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863285              

Content

show
hide
Free keywords: Lamellar bone; Collagen fibril orientation; Chemical composition; Mass density; Elastic stiffness
 Abstract: The mechanical competence of bone is crucially determined by its material composition and structural design. To investigate the interaction of the complex hierarchical architecture, the chemical composition and the resulting elastic properties of healthy femoral bone at the level of single bone lamellae and entire structural units, we combined polarized Raman spectroscopy (PRS), scanning acoustic microscopy (SAM) and synchrotron X-ray phase contrast nano tomography (SR-nanoCT). In line with earlier studies, mutual correlation analysis strongly suggested that the characteristic elastic modulations of bone lamellae within single units are the result of the twisting fibrillar orientation, rather than compositional variations, modulations of the mineral particle maturity, or mass density deviations. Furthermore, we show that predominant fibril orientations in entire tissue units can be rapidly assessed from Raman parameter maps. In all investigated tissue domains coexisting oscillating and twisted fibril patterns were observed. Ultimately, our findings demonstrate in particular the potential of combined PRS and SAM measurements in providing multi-scalar analysis of correlated fundamental tissue properties. The presented approach can be applied for non-destructive investigation of small pathologic samples from bone biopsies and of a broad range of biological materials and tissues.

Details

show
hide
Language(s):
 Dates: 2016-08-032016
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.actbio.2016.08.001
BibTex Citekey: Schrof2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Acta Biomaterialia
  Other : Acta Biomater.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 44 Sequence Number: - Start / End Page: 51 - 64 Identifier: ISSN: 1742-7061