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  Lamina-dependent calibrated BOLD response in human primary motor cortex

Guidi, M., Huber, L., Lampe, L., Gauthier, C., & Möller, H. E. (2016). Lamina-dependent calibrated BOLD response in human primary motor cortex. NeuroImage, 141, 250-261. doi:10.1016/j.neuroimage.2016.06.030.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1D59-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19E3-1
Genre: Journal Article

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http://authors.elsevier.com/a/1TVU23lc~qxcdE (Publisher version)
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 Creators:
Guidi, Maria1, Author              
Huber, Laurentius1, Author              
Lampe, Leonie1, Author              
Gauthier, Claudine2, 3, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Richard J. Renaud Science Complex, Concordia University, Montréal, QC, Canada, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

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Free keywords: Cortical layers; Calibrated fMRI; SS-SI-VASO; Hypercapnia; Oxygen metabolism; 7 T MRI
 Abstract: Disentangling neural activity at different cortical depths during a functional task has recently generated growing interest, since this would allow to separate feedforward and feedback activity. The majority of layer-dependent studies have, so far, relied on gradient-recalled echo (GRE) blood-oxygenation-level dependent (BOLD) acquisitions, which are weighted towards the large draining veins at the cortical surface. The current study aims to obtain quantitative brain activity responses in the primary motor cortex on a laminar scale without the contamination due to accompanying secondary vascular effects. Evoked oxidative metabolism was evaluated using the Davis model, to investigate its applicability, advantages, and limits in lamina-dependent fMRI. Average values for the calibration parameter, M, and for changes in the cerebral metabolic rate of oxygen consumption (CMRO2) during a unilateral finger-tapping task were (11 ± 2)% and (30 ± 7)%, respectively, with distinct variation features across the cortical depth. The results presented here showed an uncoupling between BOLD-based functional magnetic resonance imaging (fMRI) and metabolic changes across cortical depth, while the tight coupling between CMRO2 and CBV was conserved across cortical layers. We conclude that the Davis model can help to obtain estimates of lamina-dependent metabolic changes without contamination from large draining veins, with high consistency and reproducibility across participants.

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Language(s): eng - English
 Dates: 2016-01-052016-06-172016-06-272016-11-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2016.06.030
PMID: 27364473
Other: Epub 2016
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 141 Sequence Number: - Start / End Page: 250 - 261 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166