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  Interaction of ion channels and receptors with PDZ domain proteins

Kornau, H. C., Seeburg, P. H., & Kennedy, M. B. (1997). Interaction of ion channels and receptors with PDZ domain proteins. Current Opinion in Neurobiology, 7(3), 368-373. doi:10.1016/S0959-4388(97)80064-5.

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Genre: Journal Article
Alternative Title : Interaction of ion channels and receptors with PDZ domain proteins

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CurrOpinNeurobiol_7_1997_368.pdf (Any fulltext), 796KB
 
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 Creators:
Kornau, Hans Christian1, Author              
Seeburg, Peter H.1, Author              
Kennedy, Mary B., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.

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Language(s): eng - English
 Dates: 1997-06-01
 Publication Status: Published in print
 Pages: 6
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 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Current Opinion in Neurobiology
  Other : Curr. Opin.Neurobiol.
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier Current Trends
Pages: - Volume / Issue: 7 (3) Sequence Number: - Start / End Page: 368 - 373 Identifier: ISSN: 0959-4388
CoNE: https://pure.mpg.de/cone/journals/resource/954925578066