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  Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients

Fujimoto, S., Kon, N., Otaka, Y., Yamaguchi, T., Nakayama, T., Kondo, K., et al. (2016). Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients. Frontiers in Neuroscience, 10: 128. doi:10.3389/fnins.2016.00128.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1EFF-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1F0A-1
Genre: Journal Article

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 Creators:
Fujimoto, Shuhei1, 2, 3, 4, Author
Kon, Noriko3, Author
Otaka, Yohei1, 5, Author
Yamaguchi, Tomofumi1, 5, Author
Nakayama, Takeo3, Author
Kondo, Kunitsugu1, Author
Ragert, Patrick6, 7, Author              
Tanaka, Satoshi2, Author
Affiliations:
1Tokyo Bay Rehabilitation Hospital, Chiba, Japan, ou_persistent22              
2Laboratory of Psychology, Hamamatsu University School of Medicine, Japan, ou_persistent22              
3Department of Public Health, Graduate School of Medicine, Kyoto University, Japan, ou_persistent22              
4Medley, Inc., Tokyo, Japan, ou_persistent22              
5Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Institute of General Kinesiology and Athletics Training, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cortical plasticity; Inter-hemispheric inhibition (IHI); Palsy; Grating orientation; Transcranial direct current stimulation (tDCS); Transcranial magnetic stimulation (TMS)
 Abstract: In healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with sensory deficits remains unknown. The purpose of this study was to investigate whether dual hemisphere tDCS over S1 and S2 could enhance tactile discrimination in stroke patients. We employed a double-blind, crossover, sham-controlled experimental design. Eight chronic stroke patients with sensory deficits participated in this study. We used a grating orientation task (GOT) to measure the tactile discriminative threshold of the affected and non-affected index fingers before, during, and 10 min after four tDCS conditions. For both the S1 and S2 conditions, we placed an anodal electrode over the lesioned hemisphere and a cathodal electrode over the opposite hemisphere. We applied tDCS at an intensity of 2 mA for 15 min in both S1 and S2 conditions. We included two sham conditions in which the positions of the electrodes and the current intensity were identical to that in the S1 and S2 conditions except that current was delivered for the initial 15 s only. We found that GOT thresholds for the affected index finger during and 10 min after the S1 and S2 conditions were significantly lower compared with each sham condition. GOT thresholds were not significantly different between the S1 and S2 conditions at any time point. We concluded that dual-hemisphere tDCS over S1 and S2 can transiently enhance tactile discriminative task performance in chronic stroke patients with sensory dysfunction.

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Language(s): eng - English
 Dates: 2015-12-142016-03-142016-03-31
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2016.00128
PMID: 27064531
PMC: PMC4814559
Other: eCollection 2016
 Degree: -

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 128 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548