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  Partial-volume effect correction improves quantitative analysis of 18F-florbetaben β-amyloid PET scans

Rullmann, M., Dukart, J., Hoffmann, K.-T., Luthardt, J., Tiepolt, S., Patt, M., et al. (2016). Partial-volume effect correction improves quantitative analysis of 18F-florbetaben β-amyloid PET scans. Journal of Nuclear Medicine, 57(2), 198-203. doi:10.2967/jnumed.115.161893.

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Rullmann, Michael1, Author
Dukart, Jürgen2, 3, Author           
Hoffmann, Karl-Titus4, Author
Luthardt, Julia1, Author
Tiepolt, Solveig1, Author
Patt, Marianne1, Author
Gertz, Hermann-Josef5, Author
Schroeter, Matthias L.3, 6, Author           
Seibyl, John7, Author
Schulz-Schaeffer, Walter J.8, Author
Sabri, Osama1, Author
Barthel, Henryk1, Author
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
5Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Molecular NeuroImaging, LLC, New Haven, CT, USA, ou_persistent22              
8Department of Neuropathology, University Medical Center, Göttingen, Germany, ou_persistent22              


Free keywords: Partial-volume effect correction; PET; Positron emission tomography; β-amyloid; Florbetaben
 Abstract: Neocortical atrophy reduces PET signal intensity, potentially affecting the diagnostic efficacy of β-amyloid (Aβ) brain PET imaging. This study investigated whether partial-volume effect correction (PVEC), adjusting for this atrophy bias, improves the accuracy of 18F-florbetaben Aβ PET. Methods: We analyzed 18F-florbetaben PET and MRI data obtained from 3 cohorts. The first was 10 patients with probable Alzheimer disease (AD) and 10 age-matched healthy controls (HCs), the second was 31 subjects who underwent in vivo imaging and postmortem histopathology for Aβ plaques, and the third was 5 subjects who underwent PET and MRI at baseline and 1 y later. The imaging data were coregistered and segmented. PVEC was performed using the voxel-based modified Müller-Gärtner method (PVELab, SPM8). From the PET data, regional and composite SUV ratios (SUVRs) with and without PVEC were obtained. In the MRI data, mesial temporal lobe atrophy was determined by the Scheltens mesial temporal atrophy scale and gray matter volumes by voxel-based morphometry. Results: In cohort 1, PVEC increased the effect on AD-versus-HC discrimination from a Cohen d value of 1.68 to 2.0 for composite SUVRs and from 0.04 to 1.04 for mesial temporal cortex SUVRs. The PVEC-related increase in mesial temporal cortex SUVR correlated with the Scheltens score (r = 0.84, P < 0.001), and that of composite SUVR correlated with the composite gray matter volume (r = −0.75, P < 0.001). In cohort 2, PVEC increased the correlation coefficient between mesial temporal cortex SUVR and histopathology score for Aβ plaque load from 0.28 (P = 0.09) to 0.37 (P = 0.03). In cohort 3, PVEC did not affect the composite SUVR dynamics over time for the Aβ-negative subject. This finding was in contrast to the 4 Aβ-positive subjects, in 2 of whom PVEC changed the composite SUVR dynamics. Conclusion: The influence of PVEC on 18F-florbetaben PET data is associated with the degree of brain atrophy. Thus, PVEC increases the ability of 18F-florbetaben PET to discriminate between AD patients and HCs, to detect Aβ plaques in the atrophic mesial temporal cortex, and potentially to evaluate changes in brain Aβ load over time. As such, the use of PVEC should be considered for quantitative 18F-florbetaben PET scans, especially in assessing patients with brain atrophy.


Language(s): eng - English
 Dates: 2015-11-052016-02-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.2967/jnumed.115.161893
PMID: 26541776
Other: Epub 2015
 Degree: -



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Title: Journal of Nuclear Medicine
  Other : J. Nucl. Med.
Source Genre: Journal
Publ. Info: New York : Society of Nuclear Medicine
Pages: - Volume / Issue: 57 (2) Sequence Number: - Start / End Page: 198 - 203 Identifier: ISSN: 0161-5505
CoNE: https://pure.mpg.de/cone/journals/resource/991042725914954