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  Comparison of single-shot rapid acquisition with relaxation enhancement and echo planar current density MRI sequences for monitoring of electric pulse delivery in irreversible electroporation

Serša, I., Bajd, F., Kranjc, M., Busse, H., Garnov, N., Trampel, R., et al. (2016). Comparison of single-shot rapid acquisition with relaxation enhancement and echo planar current density MRI sequences for monitoring of electric pulse delivery in irreversible electroporation. In T. Jarm, & P. Kramar (Eds.), 1st World congress on electroporation and pulsed electric fields in biology, medicine and food & environmental technologies (pp. 83-86). Singapore: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-2209-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-D080-9
Genre: Conference Paper

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 Creators:
Serša, I.1, Author
Bajd, F.1, Author
Kranjc, M.2, Author
Busse, H.3, Author
Garnov, N.3, Author
Trampel, Robert4, Author              
Miklavčič, D.2, Author
Affiliations:
1Jožef Stefan Institute, Ljubljana, Slovenia, ou_persistent22              
2Faculty of Electrical Engineering, University of Ljubljana, Slovenia, ou_persistent22              
3Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: MRI; Current density imaging; Electroporation; Electric field monitoring
 Abstract: Success of electroporation treatment critically depends on coverage of the target tissue with electric field. The electric field during delivery of the electroporation pulses can be reconstructed by the magnetic resonance electric impedance tomography, a method that uses current density distribution data and electric potentials at the electrodes for reconstruction of electric field in the sample. In this study, two complementary MRI methods for current density imaging during delivery of irreversible electroporation pulses are presented. One of the methods is based on the single-shot rapid acquisition with relaxation enhancement while the other is based on the echo planar imaging MRI method. The methods were compared in terms of their sensitivity and susceptibility to image artifacts by experiments on a liver test sample that were performed on a 2.35 T small bore MRI scanner. In the experiments, a standard protocol for irreversible electroporation where 90 electric pulses of 100 μs, 3000 V are delivered at 1 Hz was performed. Results of the study confirmed that both methods have comparable sensitivity. The RARE-based method was found less susceptible to artifacts while the EPI-based method has lower SAR value and may therefore be a better candidate for use in clinics.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/978-981-287-817-5_19
 Degree: -

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Title: 1st World congress on electroporation and pulsed electric fields in biology, medicine and food & environmental technologies
Source Genre: Proceedings
 Creator(s):
Jarm, Tomaz, Editor
Kramar, Peter, Editor
Affiliations:
-
Publ. Info: Singapore : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 83 - 86 Identifier: ISBN: 978-981-287-816-8