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  Serum BDNF correlates with connectivity in the (pre)motor hub in the aging human brain: A resting-state fMRI pilot study

Mueller, K., Arélin, K., Möller, H. E., Sacher, J., Kratzsch, J., Luck, T., et al. (2016). Serum BDNF correlates with connectivity in the (pre)motor hub in the aging human brain: A resting-state fMRI pilot study. Neurobiology of Aging, 38, 181-187. doi:10.1016/j.neurobiolaging.2015.11.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-2213-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19DC-A
Genre: Journal Article

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 Creators:
Mueller, Karsten1, Author              
Arélin, Katrin2, 3, 4, Author              
Möller, Harald E.1, Author              
Sacher, Julia2, 3, Author              
Kratzsch, Jürgen5, Author
Luck, Tobias4, 6, Author
Riedel-Heller, Steffi4, 6, Author
Villringer, Arno2, 3, 4, Author              
Schroeter, Matthias L.2, 3, 4, 7, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
7Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Brain-derived neurotrophic factor (BDNF); Brain connectivity; Motor cortex; Eigenvector centrality (EC); Functional magnetic resonance imaging (fMRI); Resting-state fMRI
 Abstract: Brain-derived neurotrophic factor (BDNF) has been discussed to be involved in plasticity processes in the human brain, in particular during aging. Recently, aging and its (neurodegenerative) diseases have increasingly been conceptualized as disconnection syndromes. Here, connectivity changes in neural networks (the connectome) are suggested to be the most relevant and characteristic features for such processes or diseases. To further elucidate the impact of aging on neural networks, we investigated the interaction between plasticity processes, brain connectivity, and healthy aging by measuring levels of serum BDNF and resting-state fMRI data in 25 young (mean age 24.8 ± 2.7 (SD) years) and 23 old healthy participants (mean age, 68.6 ± 4.1 years). To identify neural hubs most essentially related to serum BDNF, we applied graph theory approaches, namely the new data-driven and parameter-free approach eigenvector centrality (EC) mapping. The analysis revealed a positive correlation between serum BDNF and EC in the premotor and motor cortex in older participants in contrast to young volunteers, where we did not detect any association. This positive relationship between serum BDNF and EC appears to be specific for older adults. Our results might indicate that the amount of physical activity and learning capacities, leading to higher BDNF levels, increases brain connectivity in (pre)motor areas in healthy aging in agreement with rodent animal studies. Pilot results have to be replicated in a larger sample including behavioral data to disentangle the cause for the relationship between BDNF levels and connectivity.

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Language(s): eng - English
 Dates: 2015-10-302015-02-252015-11-052015-11-112016-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2015.11.003
PMID: 26827656
Other: Epub 2015
 Degree: -

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 38 Sequence Number: - Start / End Page: 181 - 187 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902