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  Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections

Bröcker, F., Martin, C. E., Wegner, E., Mattner, J., Baek, J. Y., Pereira, C. L., et al. (2016). Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections. Cell Chemical Biology, 23(8), 1014-1022. doi:10.1016/j.chembiol.2016.07.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-2B2F-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-4429-8
Genre: Journal Article

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 Creators:
Bröcker, Felix1, Author              
Martin, Christopher E.2, Author              
Wegner, Erik, Author
Mattner, Jochen, Author
Baek, Ju Yuel2, Author              
Pereira, Claney L.2, Author              
Chakkumkal, Anish1, Author              
Seeberger, Peter H.3, Author              
Affiliations:
1Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
3Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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Free keywords: Clostridium difficile; lipoteichoic acid; LTA; vaccine; carbohydrates
 Abstract: Infections with Clostridium difficile increasingly cause morbidity and mortality worldwide. Bacterial surface glycans including lipoteichoic acid (LTA) were identified as auspicious vaccine antigens to prevent colonization. Here, we report on the potential of synthetic LTA glycans as vaccine candidates. We identified LTA-specific antibodies in the blood of C. difficile patients. Therefore, we evaluated the immunogenicity of a semi-synthetic LTA-CRM197 glycoconjugate. The conjugate elicited LTA-specific antibodies in mice that recognized natural LTA epitopes on the surface of C. difficile bacteria and inhibited intestinal colonization of C. difficile in mice in vivo. Our findings underscore the promise of synthetic LTA glycans as C. difficile vaccine candidates.

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 Dates: 2016-08-112016-08-18
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.chembiol.2016.07.009
BibTex Citekey: Broecker2016
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Title: Cell Chemical Biology
Source Genre: Journal
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Publ. Info: Cambridge, Massachusetts : Cell Press
Pages: - Volume / Issue: 23 (8) Sequence Number: - Start / End Page: 1014 - 1022 Identifier: ISSN: 2451-9456