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  Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage

Wessel, J. R., Ullsperger, M., Obrig, H., Villringer, A., Quinque, E. M., Schroeter, M. L., et al. (2016). Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage. Neurobiology of Aging, 38, 205-213. doi:10.1016/j.neurobiolaging.2015.10.014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-22F7-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19D5-1
Genre: Journal Article

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 Creators:
Wessel, Jan R.1, 2, Author
Ullsperger, Markus3, 4, 5, Author
Obrig, Hellmuth6, 7, Author              
Villringer, Arno6, 8, 9, Author              
Quinque, Eva Maria6, Author              
Schroeter, Matthias L.6, 7, 8, 9, Author              
Bretschneider, Katharina J.6, Author
Arélin, Katrin6, 7, 8, Author              
Roggenhofer, Elisabeth6, 7, 10, Author              
Frisch, Stefan6, 11, Author              
Klein, Tilmann A.6, 8, Author              
Affiliations:
1Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA, ou_persistent22              
2Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, ou_persistent22              
3Department of Neuropsychology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              
5Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
8Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
9Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              
10Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
11Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              

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Free keywords: Executive functions; Cognitive control; Small-vessel disease; Novelty; Errors; EEG synchrony
 Abstract: In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can impair the associated cognitive functions. Here, we investigated whether structural disconnection within this network because of small-vessel disease impairs the neural processes that subserve motor slowing after errors and novelty (post-error slowing, PES; post-novel slowing, PNS). Participants with intact frontostriatal circuitry showed increased right-lateralized beta-band (12–24 Hz) synchrony between frontocentral and frontolateral electrode sites in the electroencephalogram after errors and novelty, indexing increased neural communication. Importantly, this synchrony correlated with PES and PNS across participants. Furthermore, such synchrony was reduced in participants with frontostriatal white matter damage, in line with reduced PES and PNS. The results demonstrate that behavioral change after errors and novelty result from coordinated neural activity across a frontostriatal brain network and that such cognitive control is impaired by reduced white matter integrity.

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Language(s): eng - English
 Dates: 2015-10-062015-02-112015-10-162015-10-232016-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2015.10.014
PMID: 26563990
Other: Epub 2015
 Degree: -

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 38 Sequence Number: - Start / End Page: 205 - 213 Identifier: ISSN: 0197-4580
CoNE: /journals/resource/954925491902