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X-ray crystallography; cryo-electron microscopy; eukaryotic RNA polymerase complex; integrated structural biology; multiprotein assembly
Abstract:
The determination of detailed 3D structures of large and transient multicomponent complexes remains challenging. Here I describe the approaches that were used and developed by our laboratory to achieve structure solution of eukaryotic transcription complexes. I hope this collection serves as a resource for structural biologists seeking solutions for difficult structure determination projects.
